BMRB Entry 25189
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PDB ID:
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR25189
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Title: Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit into HLA-DR 1*03 molecules induces antibody production and protection PubMed: 15694510
Deposition date: 2014-09-01 Original release date: 2014-10-07
Authors: Cifuentes, Gladys; Salazar, Luz Mary; Vargas, Luis Eduardo; Parra, Carlos Alberto; Vanegas, Magnolia; Cortes, Jimena; Patarroyo, Manuel Elkin
Citation: Cifuentes, Gladys; Salazar, Luz Mary; Vargas, Luis Eduardo; Parra, Carlos Alberto; Vanegas, Magnolia; Cortes, Jimena; Patarroyo, Manuel Elkin. "Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit into HLA-DRbeta1*03 molecules induces antibody production and protection" Vaccine 23, 1579-1587 (2005).
Assembly members:
entity, polymer, 20 residues, 2446.658 Da.
Natural source: Common Name: not available Taxonomy ID: not available Superkingdom: not available Kingdom: not available Genus/species: not available not available
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
entity: YTNQNINISQERDLQKHGFH
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 123 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | entity | 1 |
Entities:
Entity 1, entity 20 residues - 2446.658 Da.
| 1 | TYR | THR | ASN | GLN | ASN | ILE | ASN | ILE | SER | GLN | |
| 2 | GLU | ARG | ASP | LEU | GLN | LYS | HIS | GLY | PHE | HIS |
Samples:
sample_1: DMSO 100%; Entity mM
sample_conditions_1: pH: 3.7; pressure: 1 atm; temperature: 295 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| 2D DQF-COSY | sample_1 | isotropic | sample_conditions_1 |
| 2D 1H-1H TOCSY | sample_1 | isotropic | sample_conditions_1 |
| 2D 1H-1H NOESY | sample_1 | isotropic | sample_conditions_1 |
Software:
InsightII, Accelrys Software Inc. - geometry optimization, refinement
NMR spectrometers:
- Bruker DRX 600 MHz