BMRB Entry 5985
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR5985
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Title: Solution Conformation of alpha-Conotoxin GIC, a Novel Potent Antagonist of alpha3beta2 Nicotinic Acetylcholine Receptors PubMed: 14992691
Deposition date: 2003-10-27 Original release date: 2008-07-16
Authors: Chi, S.-W.; Kim, D.-H.; Olivera, B.; McIntosh, J.; Han, K.-H.
Citation: Chi, S.-W.; Kim, D.-H.; Olivera, B.; McIntosh, J.; Han, K.-H.. "Solution Conformation of alpha-Conotoxin GIC, a Novel Potent Antagonist of alpha3beta2 Nicotinic Acetylcholine Receptors" Biochem. J. 380, 347-352 (2004).
Assembly members:
alpha-conotoxin GIC, polymer, 17 residues, Formula weight is not available
Natural source: Common Name: Geography cone Taxonomy ID: 6491 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Conus geographus
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
alpha-conotoxin GIC: GCCSHPACAGNNQHICX
- assigned_chemical_shifts
- coupling_constants
| Data type | Count |
| 1H chemical shifts | 77 |
| coupling constants | 13 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | alpha-conotoxin GIC | 1 |
Entities:
Entity 1, alpha-conotoxin GIC 17 residues - Formula weight is not available
| 1 | GLY | CYS | CYS | SER | HIS | PRO | ALA | CYS | ALA | GLY | ||||
| 2 | ASN | ASN | GLN | HIS | ILE | CYS | NH2 |
Samples:
sample_1: alpha-conotoxin GIC 11.5 mM
sample_cond_1: ionic strength: 0 M; pH: 3.5; pressure: 1 atm; temperature: 293 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| 2D NOESY | sample_1 | not available | sample_cond_1 |
| 2D TOCSY | sample_1 | not available | sample_cond_1 |
| DQF-COSY | sample_1 | not available | sample_cond_1 |
Software:
VNMR v6.1B - data collection
FELIX v98.0 - data processing
CNS v1.1 - structure refinement
NMR spectrometers:
- Varian INOVA 600 MHz