Biological_function,Sf_ID,Entry_ID,Assembly_ID H+ transportation,410,10021,1 replication factor,529,10027,1 removal of N-terminal pyroglutamic acid from polypeptide,1056,10052,1 Outer-membrane lipoprotein carrier protein,1593,10078,1 Outer-membrane lipoprotein receptor,1970,10096,1 removal of N-terminal pyroglutamic acid from polypeptide,2385,10116,1 removal of N-terminal pyroglutamic acid from polypeptide,2403,10117,1 Membrane fusion,7371,11004,1 cell surface receptor,7406,11006,1 p53 and p73 regulation,7544,11012,1 regulation of epithelial morphogenesis,7544,11012,1 sequence specific dna binding transcriptional activator or repressor,7544,11012,1 Interaction of TAR with TAR*GA aptamer : inhibition of HIV transcription,7582,11014,1 copper chaperone,7688,11019,1 copper(I) chaperone,7724,11020,1 DNA binding domain,7786,11024,1 response regulator,7786,11024,1 amyloid fibrils,7839,11028,1 heterokaryon incompatibility,7839,11028,1 prion protein,7839,11028,1 DNA-binding,7959,11034,1 amyloid fibrils,8488,11064,1 heterokaryon incompatibility,8488,11064,1 prion protein,8488,11064,1 potassium ion transport,8530,11067,1 endonuclease,17430,11545,1 antimicrobial peptide,17547,11551,1 neurotransmitter release,18830,12003,1 ubiquitin C-terminal hydrolase,18856,12009,1 malarial invasion,20884,15007,1 phosphotransferase,20900,15008,1 Phosphotransferase,20928,15010,1 Phosphotransferase,20942,15011,1 positive regulation of IkappB kinase/NF-kappaB cascade,20993,15014,1 signal transduction,20993,15014,1 envelope virus,21255,15034,1 Unknown,21301,15037,1 peptidylprolyl isomerase,21315,15038,1 ATP synthesis/hydrolysis,21441,15046,1 replication initiation,21584,15055,1 splicing,22051,15080,1 DNA BINDING,22110,15083,1 TRANSCRIPTION INITIATION,22110,15083,1 bile acid binding,22135,15084,1 superoxide dismutase,22651,15112,1 antimicrobial,22718,15115,1 Fusion Peptide complex with VIR165,22869,15124,1 Inhibition of HIV Proliferation,22869,15124,1 signal regulation,22947,15128,1 may include antibiotic activity mediated through either prtoein-bound lipids or release of lipids as response to pathogens,23230,15143,1 Membrane adhesion protein,23492,15158,1 DNA binding,23880,15177,1 transcriptional repressor,23880,15177,1 zinc homeostasis,23880,15177,1 regulation of kinase activity,23961,15183,1 Methionine-R-sulfoxide reductases,24176,15193,1 unknown,24421,15207,1 gastric acid secretion,25024,15241,1 OMP insertion and folding,25122,15247,1 Ion Channel gating,25155,15249,1 protection of pheromone components against degradation by enzymes in the sensillum,25262,15256,1 transport of pheromone compounds to the olfactory receptor,25262,15256,1 nonconventional toxin,25868,15286,1 Inhibition of HECT domain activity,26212,15306,1 Phospholipid binding,26212,15306,1 Antitermination,26248,15312,1 apoptosis,26265,15313,1 Putative Amidase,26674,15335,1 RNA binding motif,26925,15343,1 Innate immune response,27217,15356,1 signaling,27217,15356,1 Matrix metalloproteinase,27311,15361,1 Blocks the nAChR,27443,15368,1 Trascriptional regulation,27532,15373,1 DNA binding domain,27648,15378,1 muscle contraction regulation,27791,15385,1 transcription regulatory protein,27809,15386,1 muscle contraction regulation,27847,15388,1 replace the H2A-H2B complex in chromatin,27952,15393,1 muscle contraction regulation,28088,15400,1 antimicrobial activity,28339,15413,1 muscle contraction regulation,28574,15427,1 facilitate intracellular lipid transport,28665,15433,1 facilitate lipid uptake and metabolic regulation,28665,15433,1 facilitate intracellular lipid transport,28692,15434,1 facilitate lipid uptake and metabolic regulation,28692,15434,1 dimerisation motif,28861,15442,1 interaction interface,28861,15442,1 Fibroblast migration - igd motif,28961,15447,1 "Antimicrobial peptide, hemolytic assay",29267,15460,1 potentiation of neurotransmitter release,29452,15470,1 presynaptic synaptic plasticity,29452,15470,1 Post translational Modification,29503,15473,1 RNA recognition motif,29728,15485,1 RNA binding protein,29767,15487,1 "signal transdcution pathways, misregulation leads to Leukemia",29788,15488,1 unknown,29850,15491,1 E2 ubiquitin conjugating enzyme,29977,15498,1 Cell cycle control effector,30030,15501,1 Chromatin Metabolism,30030,15501,1 DNA polimerase processivity factor,30030,15501,1 DNA repair,30030,15501,1 Replication Fork Maestro,30030,15501,1 Pilot protein,30065,15503,1 dimerization,30218,15511,1 unknown,30720,15539,1 iron-sulfur cluster assembly and transfer,30760,15541,1 "Antimicrobial peptide, hemolytic assay",30837,15544,1 cell adhesion,30978,15552,1 cell migration,30978,15552,1 lectin,30998,15553,1 endocytosis,31020,15554,1 actin dynamic regulation,31061,15557,1 tellutite resistant protein,31427,15574,1 "Antimicrobial peptide, hemolytic assay",31597,15583,1 protein phosphatase 2B activator,32388,15624,1 iron carrier for Gram-negative bacterium Pseudomonas aeruginosa ATCC 15692,32484,15629,1 actin binding,32927,15653,1 cytoskeltal protein,32927,15653,1 periplasmic copper detoxification,32965,15655,1 Antimicrobial peptide,33208,15667,1 Piscicolin A126 immunity protein,33312,15673,1 copper homeostasis,33595,15690,1 Translation initiation,33717,15697,1 Methionine-R-sulfoxide reductase,34038,15715,1 collagenase,34191,15722,1 electron transfer,34234,15724,1 electron transfer,34274,15725,1 histidine biosynthesis,34616,15741,1 Lyase,34616,15741,1 anti-microbial peptide,34813,15751,1 DNA-binding,34972,15761,1 transcriptional regulation,34972,15761,1 ion binding,35040,15764,1 CHIPS blocks binding of C5a to its C5aR receptor,35286,15778,1 Immuno-evasive inhibition of neutrophils,35286,15778,1 unknown,35832,15805,1 Molecular chaperone,36021,15813,1 Prolyl isomerase,36021,15813,1 Actin binding protein,36037,15814,1 Fluorescent Protein,36353,15826,1 Biomarker,36353,15826,1 DNA binding protein,37390,15871,1 splicing,37598,15882,1 alternative splicing,37598,15882,1 alternative splicing,37643,15885,1 splicing,37643,15885,1 alternative splicing,37662,15887,1 splicing,37662,15887,1 alternative splicing,37680,15888,1 splicing,37680,15888,1 alternative splicing,37698,15889,1 splicing,37698,15889,1 alternative splicing,37729,15890,1 splicing,37729,15890,1 alternative splicing,37747,15891,1 splicing,37747,15891,1 unknown,37885,15898,1 electron transfer,38054,15904,1 guanine-specific ssRNA cleavage,38090,15905,1 mitochondrial protein,38117,15906,1 protein degradation,38146,15907,1 "endo-1,4-beta-D-xylan-hydrolysis",38185,15908,1 hydrolase,38220,15909,1 enzyme,38422,15917,1 promoter DNA recognition factor,38644,15930,1 promoter DNA recognition factor,38759,15936,1 E3 Ubiquitin Ligase,38981,15948,1 proton pump,39097,15955,1 intermolecular junction between low molecular weight non-muscle tropomyosin molecules,39299,15965,1 iron-sulfur cluster assembly and transfer,39341,15967,1 Homodimer formed by coat protein monomers are basic building block of hepatitis B nucleocapsid cores,39374,15969,1 Peptide binding domain,39451,15974,1 promoter DNA recognition factor,39467,15975,1 Antimicrobial peptide,39534,15980,1 hemolytic assay,39534,15980,1 Potassium channel inhibitor,39564,15983,1 Cell adhesion,39583,15986,1 Cell migration,39583,15986,1 Matrix structure,39583,15986,1 Energy Transduction,39623,15988,1 DNA binding,39818,15999,1 transcriptional regulator,39818,15999,1 channel inactivation,40403,16031,1 "toxin acts as antagonist, its binding to nAChR blocks the binding site of acetylcholine, prevents opening of nAChRs",40914,16060,1 This is a inhibited state of toxin RelE neutralized by antitoxin RelB.,41028,16065,1 "This is a low toxicity mutant of toxin RelE, which cleaves mRNA at the ribosomal A-site.",41055,16066,1 "Antitoxin, which countacts the toxicity of RelE.",41078,16067,1 unknown,41153,16071,1 unknown,41225,16075,1 unknown,41239,16076,1 heme chaperone,41529,16096,1 organic hydroperoxide reductase,42414,16144,1 Activation of T-cells,42451,16146,1 Unknown,42996,16174,1 prepropeptide of patellamide biosynthesis,43151,16182,1 Membrane Protein,44153,16237,1 Pore forming protein,44153,16237,1 siderophore assembly?,44474,16253,1 plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS,44556,16257,1 Potent neurite growth inhibitor,44556,16257,1 RNA binding,44904,16274,1 cardiovascular regulation,44919,16275,1 DNA binding,45254,16293,1 RNA polymerase II,45254,16293,1 scaffold,45254,16293,1 splicing machinery,45254,16293,1 Transcription factor,45254,16293,1 may include antibiotic activity mediated through either prtoein-bound lipids or release of lipids as response to pathogens,45271,16294,1 lipid-/membrane binding and regulation thereof,45289,16295,1 the redox-state of the FATC influences the cellular stability of TOR,45289,16295,1 Associated with glucose metabolism,45641,16314,1 E2 ubiquitin conjugating enzyme,45792,16321,1 Binds histone mRNAs,45829,16323,1 Catalysis of post-translational disulfide bond formation,45896,16329,1 Catalysis of post-translational disulfide bond formation,45925,16330,1 transcelullar calcium transport,46100,16340,1 Calcium binding,46488,16360,1 inhibitor,47589,16409,1 transition state analogue,47589,16409,1 putative rRNA methyltransferase,47979,16430,1 tryptase inhibitor,48030,16435,1 tryptase inhibitor,48049,16436,1 tryptase inhibitor,48068,16437,1 tryptase inhibitor,48087,16438,1 guanine-specific ssRNA cleavage,48710,16469,1 unknown,48842,16476,1 "ENDO-BETA-1,3-GLUCANASE",48959,16481,1 glycosyl hydrolase,48959,16481,1 laminarase,48959,16481,1 proteasomal degradation,49041,16484,1 Growth factor,49248,16494,1 cell adhesion,49278,16496,1 Growth factor,49420,16502,1 3'-phosphodiesterase,49662,16516,1 apyrinic/apyrimidinic endonuclease,49662,16516,1 transport of intermediate in fatty acid biosynthesis,49834,16524,1 transport of intermediate in fatty acid biosynthesis,49853,16525,1 transport of intermediate in fatty acid biosynthesis,49872,16526,1 transport of intermediate in fatty acid biosynthesis,49893,16527,1 transport of intermediate in fatty acid biosynthesis,49912,16528,1 ubiquitin C-terminal hydrolases,50059,16537,1 Arf6 GTP/GDP exchanger,50317,16550,1 unknown,50692,16568,1 electron transfer,50947,16579,1 guanine-specific ssRNA cleavage,50993,16580,1 mitochondrial protein,51034,16581,1 protein degradation,51055,16582,1 "endo-1,4-beta-D-xylan-hydrolysis",51098,16583,1 hydrolase,51131,16584,1 Hydrolysis of the beta-lactam ring in beta-lactam antibiotics.,51402,16598,1 inhibition of gene expression,51632,16609,1 Localization and sequestration of Daxx.,51691,16611,1 Regulation of the corepressor function of Daxx.,51691,16611,1 proton channel,51714,16612,1 cytokine,51760,16614,1 DNA-binding protein,51777,16615,1 signal transduction,51913,16622,1 ion channel gating,51999,16628,1 Cytolysin,52046,16630,1 Hemolysin,52046,16630,1 Cyclin-dependent kinase inhibitor,52606,16657,1 regulation of cell cycle progression,52606,16657,1 Cyclin-dependent kinase inhibitor,52607,16657,2 regulation of cell cycle progression,52607,16657,2 Cyclin-dependent kinase inhibitor,52608,16657,3 regulation of cell cycle progression,52608,16657,3 Cyclin-dependent kinase inhibitor,52609,16657,4 regulation of cell cycle progression,52609,16657,4 Cyclin-dependent kinase inhibitor,52610,16657,5 regulation of cell cycle progression,52610,16657,5 Cyclin-dependent kinase inhibitor,52611,16657,6 regulation of cell cycle progression,52611,16657,6 Cyclin-dependent kinase inhibitor,52612,16657,7 regulation of cell cycle progression,52612,16657,7 mitogenic,52648,16658,1 regulation of proliferation,52648,16658,1 tumourogenic,52648,16658,1 binding to ubiquitin ligase SCF(Cdc4) through phosphorylated motifs,52670,16659,1 Cyclin-dependent kinase inhibitor,52670,16659,1 regulation of cell cycle progression,52670,16659,1 binding to ubiquitin ligase SCF(Cdc4) through phosphorylated motifs,52671,16659,2 Cyclin-dependent kinase inhibitor,52671,16659,2 regulation of cell cycle progression,52671,16659,2 binding to ubiquitin ligase SCF(Cdc4) through phosphorylated motifs,52672,16659,3 Cyclin-dependent kinase inhibitor,52672,16659,3 regulation of cell cycle progression,52672,16659,3 binding to ubiquitin ligase SCF(Cdc4) through phosphorylated motifs,52673,16659,4 Cyclin-dependent kinase inhibitor,52673,16659,4 regulation of cell cycle progression,52673,16659,4 binding to ubiquitin ligase SCF(Cdc4) through phosphorylated motifs,52674,16659,5 Cyclin-dependent kinase inhibitor,52674,16659,5 regulation of cell cycle progression,52674,16659,5 binding to ubiquitin ligase SCF(Cdc4) through phosphorylated motifs,52675,16659,6 Cyclin-dependent kinase inhibitor,52675,16659,6 regulation of cell cycle progression,52675,16659,6 binding to ubiquitin ligase SCF(Cdc4) through phosphorylated motifs,52676,16659,7 Cyclin-dependent kinase inhibitor,52676,16659,7 regulation of cell cycle progression,52676,16659,7 "Lysozyme hydrolyzes the -1,4 linkages between N-acetylmuramic acid and N- acetylglucosamine",52802,16664,1 GTPase,52876,16668,1 GTPase,52896,16669,1 beta-lactamase,52968,16673,1 Regulation of the catalytic activity of the AHAS I holoenzyme,53256,16687,1 catalyzes the extracytoplasmic formation of disulphide bonds in newly synthesized proteins,53331,16689,1 thiol-disulphide oxidoreductase,53331,16689,1 prolyl isomerase,53363,16690,1 alternate splicing,53713,16708,1 RNA binding,53713,16708,1 engineered protein,53862,16716,1 engeniered enzyme,53879,16717,1 engeniered enzyme,53896,16718,1 Zinc metallopeptidase,54138,16735,1 ADP-ribosyltransferase,54172,16737,1 antimicrobial peptide,54217,16739,1 microtubule transport,54982,16781,1 TCTP,55958,16833,1 acyl carrier protein,56471,16860,1 putative role in lipopolysaccharide synthesis,56471,16860,1 calcium sensor,56555,16862,1 Histidine kinase inhibitor,56571,16863,1 scaffolding,56876,16879,1 To inhibit the redox cyling and precipitation of the free alpha-haemoglobin chain,57216,16898,1 immunosuppression,57845,16931,1 immunosuppression,57892,16933,1 Actin binding,58427,16959,1 Integrin activation,58427,16959,1 Phospholipid binding,58427,16959,1 oxidoreductase,58512,16962,1 Proteasomal shuttling,59709,17024,1 unknown,59972,17034,1 photoreptor for chromatic adaptation,60559,17064,1 Iron chaperon,60631,17068,1 Regulator/Inhibitor of the Fe-S cluster formation,60631,17068,1 signal transduction,61076,17089,1 binds IGF-II,61499,17110,1 Phorbol ester and Diacylglycerol (DAG) binding domain.,61536,17112,1 Phorbol ester and Diacylglycerol (DAG) binding domain.,61555,17113,1 binds IGF-II,61831,17128,1 structural protein,61906,17131,1 binds IGF-II,61965,17134,1 electron transport,62108,17144,1 electron transport,62146,17146,1 Implicated in the control of cell growth.,62215,17149,1 Plays a role in the regulation of intracellular calcium levels.,62215,17149,1 Required in brain development and mature brain function,62215,17149,1 Role in CNTN1-mediated signaling.,62215,17149,1 "with important roles in the regulation of axon growth, axon guidance, and neurite extension.",62215,17149,1 Chitin-Binding protein,62457,17160,1 cortar RNA,62662,17172,1 RNase P protein subunits,63060,17190,1 metal sequestration,64560,17266,1 metal trafficking,64560,17266,1 RNA-binding,66689,17380,1 RNA-binding,66790,17385,1 RNA-binding,66808,17386,1 RNA-binding,66826,17387,1 hydrolyse peptidyl-tRNA prematurely dissociated from the ribosome,67217,17404,1 phycobilisome,67689,17429,1 LR11 plays a crucial role in APP trafficking and is a key regulator of APP processing,68011,17444,1 LR11 (SorLA) is a recently identified neuronal protein that interacts with amyloid precursor protein (APP),68011,17444,1 DNA binding,68240,17456,1 protein kinase,68499,17471,1 Transcriptional Antitermination,69544,17526,1 calcium sensor,69662,17532,1 prion,70388,17570,1 putative glyoxylase,70900,17597,1 Act as GTPase function,71307,17616,1 blue light photosensing,71739,17640,1 Iron chaperon,71758,17641,1 Regulator/Inhibitor of the Fe-S cluster formation,71758,17641,1 Blue-light detection,71787,17643,1 Na+ Ca2+ exchanger,73255,17721,1 Na+ Ca2+ exchanger,73269,17722,1 Insulin-like growth factor inhibitor,73726,17743,1 transcription corepressor activity,73949,17753,1 oxidoreductase,75400,17830,1 oxidoreductase,75417,17831,1 Sulfur transfer from L-cysteine to IscU,75652,17844,1 electron transfer,75669,17845,1 electron transfer,75690,17846,1 electron transfer,75711,17847,1 electron transfer,75732,17848,1 RNA binding,76355,17878,1 Glutaminase activity,77433,17935,1 Microtubule associated protein,77613,17945,1 coats fungal structures,78281,17978,1 reduces surface tension,78281,17978,1 anticancer,78418,17986,1 antimalaria,78418,17986,1 antimicrobial,78418,17986,1 Responsible for the binding of collagen,79152,18021,1 Electron Transport,79282,18029,1 Sulfhydryl Oxidase,79282,18029,1 presumed ribosomal assembly factor,79313,18031,1 putative involvement in oxidative stress,79313,18031,1 "Three subunits form a symmetrical beta barrel and transport extracellular domain of the protein out of the cell. Strand 4 of subunit 1 is in contact with strand 1 of the neighbouring subunit.",80754,18108,1 "YadA belongs to the family of trimeric autotransporter adhesins (TAA). The anchor domain forms a beta barrel in the outer membranes and exports the extracellular domain outside the cell.",80754,18108,1 Interacts with the beta subunit of RNA polymerase.,80995,18121,1 Essential protein for cell viability.,81440,18151,1 Interacts with the beta subunit of RNA polymerase.,81440,18151,1 protein mediates axonal path finding of developing and regenerating axons of retinal ganglion cells in goldfish,81511,18155,1 Interacts with the beta subunit of RNA polymerase.,82277,18193,1 Interacts with the beta subunit of RNA polymerase.,82300,18194,1 Heme Transport Protein HasR,82448,18201,1 Transmembrane signaling,82448,18201,1 acetyl-CoA is the first substrate of hNaa50p,82463,18202,1 Dual specificity phosphatase,83032,18228,1 inhibited cysteine protease,83199,18236,1 structural protein,83597,18260,1 Binding cell surface glycosaminoglycans during bacterial infection,84742,18329,1 attaches Z-ring to cell membrane in bacterial cell division,84929,18339,1 Motor complex of Plasmodium parasites,85644,18377,1 HscA facilitates the iron-sulfur cluster transfer from IscU.,85737,18381,1 Zn(II)-dependent transcriptional regulator,86253,18413,1 Zn(II)-dependent transcriptional regulator,86269,18414,1 Transfers a lipid linked from the donor to a growing peptide onto an asparagine residue in the consenus sequence Asn-X-Thr where X can be any amino acid except Proline.,87460,18477,1 Zinc finger,88920,18551,1 Localizes effector domain of unknown function to interior surface of membranes,89177,18562,1 Membrane localization to anionic phospholipids. Is believed to target effector domains (C2 and C3 domains) to inner cell leaflet.,89222,18565,1 "Triacylglyceride hydrolysis, lipase, esterase",89409,18574,1 "Triacylglyceride hydrolysis, lipase, esterase",89426,18575,1 Regulation of the catalytic activity of the AHAS I holoenzyme,89740,18591,1 DNA-binding,89843,18598,1 Periplasmic binding protein. Extracellular receptor for ribose.,90013,18603,1 Oxygen storage protein,193065,4062,1 "Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.",90358,18621,1 Histone mRNA metabolic process,90358,18621,1 pathogenesis,90961,18651,1 protein transport,90961,18651,1 May regulate the surface expression of some potassum channels by retaining them in the endoplasmic reticulum,91412,18676,1 protease,91412,18676,1 phosphorylation,93538,18791,1 structural part of centriolar central tube,93848,18807,1 binding to prodomains of bone morphogenetic proteins,94611,18843,1 fibrillin microfibril formation,94611,18843,1 Chromatin remodelling,95335,18874,1 Gene regulation,95335,18874,1 Tumor suppression,95335,18874,1 Initiation of the signal transduction cascade activated by the B-cell antigen receptor complex,95545,18884,1 T-cell receptor signaling upon ITAM phosphorylation,95625,18889,1 electron transport,96269,18919,1 Dimerization,96776,18947,1 gain in endonuclease activity,97156,18969,1 Modulation of transcriptional repression of specific genes,97429,18982,1 Regulating microtubule plus-end dynamics,98248,19031,1 Dephosphorylate phosphorylated tyrosine residues,98555,19046,1 Ion channel regulation,98660,19050,1 RNA binding,99467,19098,1 Protein-protein interaction module that facilitates binding to other endocytic regulators containing the asparagine-proline-phenylalanine (NPF) motif.,99656,19109,1 PHOSPHATIDYLINOSITOL 3-KINASE,99686,19110,1 "Lysozyme hydrolyzes the -1,4 linkages between N-acetylmuramic acid and N- acetylglucosamine",99983,19127,1 Fyn-SH3 ligand,101040,19186,1 controlled protein degradation; protein homeostasis,101202,19194,1 RNA recognition motif,101382,19203,1 Protein Tyrosine Phosphatase,101767,19223,1 Protein Tyrosine Phosphatase,101788,19224,1 N-terminal domain of E7 oncoprotein from HPV-16,102634,19269,1 Protein tyrosine phosphatase,102684,19272,1 chymotrypsin inhibitor,102987,19287,1 Site of carbohydrate recognition and binding in the DC-SIGNR protein,103143,19297,1 This CPR enzyme is required for electron transfer from NADPH to cytochrome P450.,103240,19301,1 Endonuclease and bifunctional nucleases,103358,19307,1 Endonuclease and bifunctional nucleases,103375,19308,1 Centriolar protein,103527,19318,1 Lysine-specific demethylase of Histone H3K4,103703,19328,1 E3 ubiquitination-promoting complex protein,103736,19329,1 calcium binding,104379,19369,1 calcium binding,104397,19370,1 calcium binding,104415,19371,1 unknown,106089,19461,1 unknown,106109,19462,1 binding to human PPIase PIN1,106270,19472,1 binding to human PPIase PIN1,106293,19473,1 a Novel Compact Myelin Protein,106501,19485,1 Homo sapiens small VCP/p97-interacting protein,106501,19485,1 muscle contraction,107105,19518,1 molecular chaperone,107928,19560,1 Non-lytic virus that infect bacteria,111299,19747,1 The RodA hydrophobin of the opportunistic pathogen Aspergillus fumigatus forms an amyloid monolayer with a rodlet morphology that covers the surface of fungal spores.,111867,19782,1 This rodlet layer bestows hydrophobicity to the spores facilitating their dispersal in the air.,111867,19782,1 Hsp 90 binding,111927,19787,1 Hsp 90 binding,111946,19788,1 Interaction with Protective Antigen and endocytosis,112128,19803,1 Zinc metallopeptidase,112128,19803,1 "Cytosolic domain of mPanx1 channel, involved in regulation of the channel opening and closure",112287,19814,1 apoptosis,114114,19927,1 "binding pocket for NAD+ metabolites: ADP-ribose, PAR, and negatively charged molecules such as RNA",114114,19927,1 chromatin repair,114114,19927,1 phosphorylate HPr in E. coli to facilitate translocation of sugars across cytoplasmic membrane,114663,19958,1 RNA processing,114813,19967,1 interaction with the 5 - untrasnlated region (UTR) of some cellular mRNAs,114813,19967,1 recognition of the 5 -ppp end of nascent RNA with a mechanism modulated by phosphorylation,114813,19967,1 Cardiovascular agent,115935,20029,1 Fluid Balance,115935,20029,1 Involved in CNS,115935,20029,1 Cardiovascular agent,115972,20030,1 Fluid Balance,115972,20030,1 Involved in CNS,115972,20030,1 Cardiovascular agent,115996,20031,1 Fluid Balance,115996,20031,1 Involved in CNS,115996,20031,1 nAChR antagonist,116042,20033,1 Toxin,116042,20033,1 affect on islet hormane secretions,116382,20051,1 reduces food intake,116382,20051,1 Antimicrobial peptide,116503,20057,1 Antimicrobial peptide,116519,20058,1 Antimicrobial peptide,116535,20059,1 Antimicrobial peptide,116564,20060,1 Antimicrobial peptide,116580,20061,1 Histone Deacetylase Inhibitor,116630,20064,1 Histone Deacetylase Inhibitor,116646,20065,1 Histone Deacetylase Inhibitor,116663,20066,1 Histone Deacetylase Inhibitor,116696,20068,1 Histone Deacetylase Inhibitor,116712,20069,1 antimicrobial action,116851,20078,1 RNA Polymerease,117340,20110,1 Neuromodulator,117437,20115,1 interacts with NK1R,117453,20116,1 neuromodulator,117453,20116,1 binds to NK1R,117470,20117,1 neuromodulator,117470,20117,1 Agonist of the nociceptin receptor,117639,20127,1 electron transfer,202881,4578,1 "The species discussed is a stable mimick of the (5-55) folding intermediate in BPTI folding",119360,2169,1 unknown,121711,25025,1 probable beta-lactamase,121741,25026,1 Catalytic break-down of beta-lactam antibiotics,122318,25063,1 Catalytic break-down of beta-lactam antibiotics,122598,25080,1 "binding pocket for NAD+ metabolites: ADP-ribose, PAR and negatively",123372,25132,1 viral replication,123372,25132,1 Assembly factor for H/ACA RNP,124002,25167,1 designed halophilic sequence derived from unique domain of human SRC kinase,124537,25196,1 lipid binding activity,124537,25196,1 Makes fibres tougher than Kevlar... in theory.,124555,25197,1 Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts,125281,25239,1 E3 Ubiquitin Ligase,125405,25248,1 transforming growth factor beta receptor signaling pathway,125405,25248,1 E3 Ubiquitin Ligase,125425,25249,1 transforming growth factor beta receptor signaling pathway,125425,25249,1 Molecular chaperone,125741,25271,1 prolyl peptidyl isomerase,125741,25271,1 histidine kinase,125858,25278,1 Oxygen transport,125984,25285,1 Oxygen transport,126003,25286,1 Bacterial protein secretion,126921,25334,1 Peptidyl-Prolyl Isomerization,126951,25336,1 Peptidyl-Prolyl Isomerization,126972,25337,1 Peptidyl-Prolyl Isomerization,126993,25338,1 Peptodyl-Prolyl Isomerization,127012,25339,1 Peptidyl-Prolyl Isomerization,127030,25340,1 E3 Ubiquitin Ligase,127253,25351,1 Transforming growth factor beta receptor signaling pathway,127253,25351,1 Energy balance in the cell,127285,25353,1 Energy balance in the cell,127341,25357,1 Inhibition of enzymatic activity of Adenylate Kinase by Ap5a,127387,25360,1 Inhibition of enzymatic activity of Adenylate Kinase by Ap5a,127403,25361,1 Inhibition of enzymatic activity of Adenylate Kinase by Ap5a,127419,25362,1 Translocation factor for bacterial protein synthesis,127519,25368,1 carbohydrate recognition domain of VP4,128739,25441,1 membrane binding domain of a perforin,129442,25481,1 Regulation of muscle contraction,129731,25495,1 peroxidase,130900,25557,1 Energy balance in the cell,132101,25628,1 Energy balance in the cell,132115,25629,1 cytotoxin,132802,25665,1 Overcome host inflammatory and immune responses,133929,25727,1 Overcome host inflammatory and immune responses,133951,25728,1 zinc-dependent metalloprotease secreted by Clostridium difficil,134626,25766,1 transcription factor,135110,25792,1 cell-mediated immunity,135471,25809,1 degrades elastin and alpha1-antitrypsin,136268,25859,1 protein of the LPS transport system,136454,25869,1 Epigenetic reader domain,138548,25988,1 The eukaryotic like serine /threonine protein kinase G promotes cellular survival of pathogenic mycobacteria by inhibiting phagosome-lysosome fusion within host macophages.,139267,26027,1 The eukaryotic like serine /threonine protein kinase G promotes cellular survival of pathogenic mycobacteria by inhibiting phagosome-lysosome fusion within host macophages.,139284,26028,1 The eukaryotic like serine /threonine protein kinase G promotes cellular survival of pathogenic mycobacteria by inhibiting phagosome-lysosome fusion within host macophages.,139303,26029,1 The eukaryotic like serine /threonine protein kinase G promotes cellular survival of pathogenic mycobacteria by inhibiting phagosome-lysosome fusion within host macophages.,139321,26030,1 cytotoxin,139568,26044,1 Translesion/bypass polymerase,141440,26564,1 cytoskeletal protein,141875,26593,1 molecular chaperone,142562,26640,1 small heat shock protein,142562,26640,1 epidermis development,142605,26642,1 keratinization,142605,26642,1 keratinocyte differentiation,142605,26642,1 "protein binding, bridging",142605,26642,1 transcription factor,142684,26647,1 zinc-sensitive transcriptional regulation,142853,26658,1 RNA splicing,143008,26672,1 nuclear puncta formation,143008,26672,1 stress granule formation,143008,26672,1 PqqD is a scaffolding protein,143264,26690,1 activation of NF-kappaB-inducing kinase activity,143503,26708,1 activation of NF-kappaB-inducing kinase activity,143518,26709,1 lytic polysaccharide monooxygenase,143770,26717,1 Calcium-binding protein,143868,26723,1 Calcium-binding protein,143891,26724,1 Transcriptional regulation,143977,26730,1 Transcriptional regulation,143991,26731,1 calcium-binding protein,144073,26738,1 m1A22 tRNA methyltransferase,144186,26744,1 Pilin assembly,144207,26745,1 Transpeptidation,144207,26745,1 hydrolase,144238,26748,1 pancreatic ribonuclease,144238,26748,1 stimulator of angiogenesis,144238,26748,1 monoxygenation,144257,26750,1 Antigen recognition,144277,26751,1 CD3 interaction,144277,26751,1 T-cell activation,144277,26751,1 T-cell receptor,144277,26751,1 Epigenetic reader domain,144331,26754,1 CELL CYCLE SIGNALING,144443,26760,1 "Skp1 is an adaptor protein in the Skp1-Cullin1-F-box (SCF) RING E3 ligase. SCF E3 ligase is involved in the polyubiquitination of protein molecules involved in various cellular processes.",144519,26765,1 Control of the cell cycle. Dephosphorylation of pTpY-Cdk2/Ciclin A complex,144772,26779,1 Carbohydrate binding,144967,26791,1 Pathogen binding,144967,26791,1 Pathogen recognition,144967,26791,1 "Molecular chaperone, assists in protein refolding, protein trafficking and protein degradation",145413,26815,1 immunoglobulin binding domain,145925,26845,1 Crucial role in assembaly of type iv secretion system complex in gram negative bacteria,146059,26852,1 Wildtype R3 binds to vinculin and RIAM and is involved in cell adhesion,146426,26880,1 adhesion protein,146485,26884,1 Co-factor of hRSV RNA dependent RNA polymerase,146710,26905,1 Anchors and positions bacterial flagellar motor C-ring relative to MS-ring,146757,26908,1 amyloid fibrils,146824,26913,1 heterokaryon incompatibility,146824,26913,1 prion protein,146824,26913,1 Lipase,146962,26923,1 The assembly binds to DNA to perform various DNA dependent Cellular activities,147240,26942,1 signaling protein,147256,26943,1 signaling protein,147273,26944,1 One of the U6 snRNA binding domains of human SART3.,147342,26948,1 Chaperone,147356,26949,1 DNA binding,147455,26957,1 Transcription factor,147455,26957,1 transcriptional repressor,147484,26959,1 SUMO-specific protease 4 (SUSP4),147528,26961,1 "catalyze the transfer of acetyl group from the acetyl-group donor, acetyl-CoA, to an arylalkylamine acceptor",147543,26962,1 Responsible for docking and inducing endocytosis of enterotoxin complex to epithelial cells,147623,26966,1 Part of Skp1/Cullin-1/F-box protein(SCF) complex involved in ubiquitin degradation.,147638,26967,1 Part of Skp1/Cullin-1/F-box protein(SCF) complex involved in ubiquitin degradation.,147655,26968,1 T cell differentiation,147803,26977,1 cell-mediated immunity,147803,26977,1 thymic selection,147803,26977,1 DNA binding protein,148065,26995,1 Transition state analogue of phosphoryl transfer,148481,27022,1 transcriptional repressor,148586,27028,1 "Aggregated state formed at neutral pH, with possibly correlations to cataract formation.",148768,27039,1 Htt exon1 protein aggregates are implicated in Huntington's Disease,148851,27045,1 Hydrolysis of beta-lactam antibiotics,149195,27067,1 "polysaccharide binding, biofilm formation",150142,27130,1 epigenetic repression,150409,27145,1 "Binding pocket for NAD+ metabolites: ADP-ribose, PAR and negatively charged molecules such as RNA",150605,27158,1 "Viral replication, Virulence",150605,27158,1 Virulence factor of the SARS coronavirus,150761,27169,1 Virulence factor of the SARS coronavirus,150883,27176,1 Virulence factor of the SARS coronavirus,150897,27177,1 Forms part of the structural core of the scaffoldin complex of the cellulosome.,150947,27180,1 proton trans location across the membrane,151701,27232,1 antigen presentation; cellular immunity,151954,27248,1 antigen presentation; cellular immunity,151973,27249,1 kinase,152367,27273,1 kinase,152384,27274,1 Presents self or heterologous peptides on cell surface for immune surveillance.,152562,27285,1 Presents self or heterologous peptides on cell surface for immune surveillance.,152584,27286,1 PKS-NPRS,152866,27304,1 Peptidyl Carrier Protein,152866,27304,1 Transport Protein,152866,27304,1 "RNA binding protein, RNA recognition motif",152916,27307,1 cochaperone,153071,27322,1 Anti-inflammatory peptide,153543,27357,1 Immunomodulatory peptide,153543,27357,1 epigenetic silencing,153660,27364,1 transcriptional regulation,153660,27364,1 epigenetic silencing,153695,27366,1 transcriptional regulation,153695,27366,1 epigenetic silencing,153715,27367,1 transcriptional regulation,153715,27367,1 epigenetic silencing,153735,27368,1 transcriptional regulation,153735,27368,1 epigenetic silencing,153755,27369,1 transcriptional regulation,153755,27369,1 epigenetic silencing,153776,27370,1 transcriptional regulation,153776,27370,1 epigenetic silencing,153797,27371,1 transcriptional regulation,153797,27371,1 epigenetic silencing,153818,27372,1 transcriptional regulation,153818,27372,1 Wnt signalling and puncta formation,154373,27402,1 cellulose-active lytic polysaccharide monooxygenase,154532,27411,1 DNA damage repair,154549,27412,1 Transcription factor,154549,27412,1 Selectively catalyzes the oxidative demethylation of the internal mRNA modification N6-methyladenosine,154566,27413,1 transcriptional repressor,155234,27455,1 transcriptional repressor,155295,27459,1 reduce flavins,155359,27462,1 reduce flavins,155375,27463,1 anti-freeze protein,155535,27473,1 ubiquitylation,155586,27477,1 "Interaction with AlyREF, UIF and RNA",155710,27484,1 Innate immune evasion,155909,27498,1 Nucleo-cytoplasmic trafficking,155909,27498,1 Viral replication,155909,27498,1 Fatty acid binding and transport,156058,27509,1 Nuclear translocation,156074,27510,1 PPAR alpha activation,156074,27510,1 ubiquitin ligation,156090,27511,1 ubiquitination,156104,27512,1 Nucleotides binding,156286,27523,1 "The Olduvai Triplet contains three human lineage-specific Olduvai domains, HLS1, HLS2, and HLS3.",156445,27533,1 The assembly binds to DNA to perform various DNA dependent Cellular activities,156829,27557,1 Adapter Protein,156926,27563,1 Protein-Protein Interactions,156926,27563,1 "The molecular complex forms pores in bacterial membranes, disrupting the membranes.",157070,27572,1 "Binds TGF-b receptors, TbRI and TbRII",157108,27574,1 Cell signaling,157108,27574,1 putative methyltransferase,157174,27578,1 Chaperone-major subunit pre-assembly complex from Csu biofilm-mediating pili of Acinetobacter baumannii,157435,27594,1 DNA binding domain,157460,27595,1 Centromeric protein,157582,27603,1 dimerisation of Nek2 kinase,157596,27605,1 Accepts and transfers ubiquitin,158490,27664,1 mRNA binding,158561,27669,1 mRNA binding,158577,27670,1 Potassium Channel,158671,27676,1 cell cycle arrest,158688,27677,1 epigenetic regulation,158688,27677,1 gene suppression,158688,27677,1 Potassium Channel,158704,27678,1 Potassium Channel,158721,27679,1 Potassium Channel,158751,27680,1 Chaperone,158768,27681,1 Small heat shock protein (sHSP),158768,27681,1 pH dependent silk formation,158809,27683,1 chemotactic gradients,158826,27684,1 cis-trans peptidyl-prolyl isomerase,159549,27732,1 Inhibit calcineurin,159570,27733,1 cis-trans peptidyl-prolyl isomerases,159593,27734,1 Inhibitor of calcineurin,159614,27737,1 cis-trans peptidyl-prolyl isomerases,159637,27738,1 Inhibition of calcineurin,159658,27739,1 entry of nuclease toxin into bacterial cytoplasm,159840,27753,1 metI dependent bacterial cytoplasm entry,159840,27753,1 entry of nuclease toxin into bacterial cytoplasm,159855,27754,1 metI dependent bacterial cytoplasm entry,159855,27754,1 entry of nuclease toxin into bacterial cytoplasm,159870,27755,1 metI dependent bacterial cytoplasm entry,159870,27755,1 Used as an engineered peptide aptamer,159906,27757,1 NSL2 is necessary for metastasis suppresion. NSL2 ( C-terminus of BRMS1),159921,27759,1 Calcium binding protein,160342,27787,1 specific ligand binding,160466,27794,1 "Cytoskeletal protein that connects ECM to actin cytoskeleton.Multiple functions in cells, such as signal transduction, force transmission and scaffolding.",160498,27795,1 C-type lectin,161375,27854,1 Calcium-dependent receptor,161375,27854,1 Pathogen recognition receptor (PRR),161375,27854,1 Inhibitor of amyloid aggregation,161651,27873,1 Regulation,161862,27884,1 Hydrolysis of beta-lactam antibiotics,161913,27888,1 Hydrolysis of beta-lactam antibiotics,161940,27890,1 dimerization domain of transcription factor,162152,27915,1 transcription factor,162176,27916,1 The wild-type enzyme catalyses the reversible interconversion of beta-glucose 1-phosphate and beta-glucose 6-phosphate,162214,27920,1 Cellular adhesion,162436,27935,1 Quaternary interaction with A3VP1 domain,162436,27935,1 biofilm-associated amyloid formation,162436,27935,1 phosphatase; hydrolase,162558,27950,1 Co-chaperone,162591,27952,1 DNA repair protein,162997,27978,1 Vpr-binding,162997,27978,1 cytotoxic effector,163020,27979,1 Chaperone,163392,28001,1 Binding ribosomal proteins,163474,28011,1 E3-ubiquitin ligase,163474,28011,1 Acts with HECT-type and RBR family E3 ubiquitin-protein ligases,163692,28028,1 E2-conjugating enzyme activity,163692,28028,1 Protein polyubiquitination,163692,28028,1 "P-dimers can interact with bile acids, which are either required for infection or promote infectivity, depending on the viral strain",163708,28030,1 "P-dimers from human Norovirus are responsible for the interaction of histo blood group antigens, a cell attachment factor require d for infection",163708,28030,1 iron uptake,164058,28056,1 solute binding for ABC transporter,164058,28056,1 iron uptake,164074,28057,1 solute binding for ABC transporter,164074,28057,1 allergen,164241,28092,1 The wild-type enzyme catalyses the reversible interconversion of beta-glucose 1-phosphate and beta-glucose 6-phosphate,164273,28095,1 The wild-type enzyme catalyses the reversible interconversion of beta-glucose 1-phosphate and beta-glucose 6-phosphate,164290,28096,1 The wild-type enzyme catalyses the reversible interconversion of beta-glucose 1-phosphate and beta-glucose 6-phosphate,164307,28097,1 major histocompatibility complex,164347,28107,1 major histocompatibility complex,164364,28108,1 major histocompatibility complex,164412,28114,1 protein docking domain,179724,3322,1 Trypsin inhibitor,192297,397,1 calcium-binding protein,192345,4001,1 Staphylococcal nuclease fragment,192375,4010,1 binding domain of a glucohydrolase,192390,4011,1 C2-H2 zinc finger,192498,4024,1 DNA binding,192498,4024,1 transcription regulator,192498,4024,1 RNA-binding protein,192552,4029,1 calcium-binding protein,192568,4030,1 DNA binding domain,192614,4033,1 DNA binding domain,192627,4034,1 "E2 is a transcription factor for the Human papillomavirus,and is required for replication of DNA",192640,4035,1 regulatory protein,192713,4040,1 inactivates sodium ion permeability,192760,4043,1 Inhibits Uracil-DNA Glycosylase,192774,4044,1 "mediate protein-protein interactions and the translocation of proteins across cellular membranes",192801,4046,1 "Rubredoxin is a component of the electron transport system and its function is undetermined",192876,4050,1 "Rubredoxin is a component of the electron transport system and its function is undetermined",192891,4051,1 lipolytic enzyme,193031,4060,1 Oxygen storage protein,193046,4061,1 degradation of extracellular matrix associated with normal tissue remodeling,193097,4064,1 "Rubredoxin is a component of the electron transport system and its function is undetermined",193126,4066,1 Elicits intense sweet-tasting response,193143,4067,1 "Ovomucoid third domains have potent inhibitory activity toward serine proteinases",193167,4068,1 analogue of Insulin-Like Growth Factor I,193185,4069,1 mediates the assembly of type-I pili in E. coli,193215,4070,1 antifungal,193231,4071,1 plant defensin,193231,4071,1 RNA-1 modulator protein,193246,4072,1 cholesterol biosynthesis,193262,4073,1 electron transfer,193262,4073,1 cholesterol biosynthesis,193286,4074,1 electron transfer,193286,4074,1 "'Class II PLA2 play a role in the release of arachidonic acid, a precursor in the formation of inflammatory mediators such as prostaglandins and thromboxanes'",193334,4078,1 "A-domain of HMG1 (high mobility group, non-histone chromosomal protein) are DNA binding proteins involved in replication,transcription, and chromatin assembly",193348,4079,1 "Troponin C is a a thin filament calcium-binding protein responsible for triggering muscle contraction from the sarcoplasmic reticulum",193378,4080,1 cytokine,193393,4081,1 "Plays a major role in the signaling pathway leading to cytoskeletal rearrangement",193409,4082,1 "Recombinant E. coli CheY, a 128 residue protein is involved in regulating bacterial chemotaxis by binding to the flagellar motor of a bacteria.",193427,4083,1 regulates sexual differentiation in Drosophila,193461,4085,1 Sxl-RBD2,193461,4085,1 p16 is a multiple tumor suppressor,193477,4086,1 Exhibits angiogenic and a variety of growth and differentiation activities,193551,4091,1 heterodimerization domain of core binding factor beta subunit,193565,4092,1 "Rnase H domain of HIV-1 reverse transcriptase plays an important role in viral replication",193578,4093,1 IL-4 plays a major role in the immune and inflammatory systems,193591,4094,1 RNA binding domain,193605,4095,1 cleaves the RNA moiety of RNA:DNA hybrids,193620,4097,1 cellular growth and differentiation,193641,4098,1 hydrolysis of beta-lactam antibiotics,193740,4102,1 "DNA operator sequence interacts with the Antennapedia Homeodomain. This DNA sequence is part of a developmental regulatory system responsible for the body plan in Drosophila melanogaster during embryogenesis.",193759,4103,1 "DNA operator sequence interacts with the Antennapedia Homeodomain. This DNA sequence is part of a developmental regulatory system responsible for the body plan in Drosophila melanogaster during embryogenesis.",193775,4104,1 phosphorylate HPr in E. coli to facilitate translocation of sugars across cytoplasmic membrane,193809,4106,1 transcription regulator,193831,4107,1 transcription regulator,193846,4108,1 cell adhesion molecule,193861,4109,1 cell adhesion,193920,4111,1 repressor of the cyanobacterial metallothionein gene,194164,4128,1 Calcium binding protein,194179,4129,1 LysN is the N-terminal anticodon binding domain of the lysyl-tRNA synthetase,194273,4134,1 multidrug antiporter,194309,4136,1 multidrug resistance,194309,4136,1 "Rubredoxin is a component of the electron transport system and its function is undetermined",194327,4137,1 RNase,194345,4138,1 Ca2+ binding protein,194373,4140,1 DNA-binding,194391,4141,1 embryonic development,194391,4141,1 "unknown, possible role in the plant defense against pathogens or in the formation of cutin layers.",194418,4142,1 Cell adhesion,194433,4143,1 Heterophilic binding,194433,4143,1 Homophilic binding,194433,4143,1 RNA polymerase subunit,194447,4144,1 electron transfer protein,194526,4149,1 cytokine receptor homology domain,194559,4150,1 receptor,194559,4150,1 signaltransducer,194559,4150,1 transcription factor,194608,4153,1 Electron transfer to cytochrome P450cam,194629,4154,1 "Chemoattractant Cytokine (Chemokine)Specific chemoattractant for Eosinophils, Selectively binds CCR3",194647,4155,1 disulfide bond formation,194666,4156,1 antimicrobial peptide,194681,4157,1 Cytotoxic endoribonuclease,194696,4158,1 Ribosome Inactivating Protein,194696,4158,1 neurotoxin,194712,4159,1 Cell adhesion,194782,4162,1 Heterophilic binding,194782,4162,1 Homophilic binding,194782,4162,1 antimicrobial,194798,4163,1 non-morphogenic class,194798,4163,1 plant defensin,194798,4163,1 bacterial iron transport,194814,4164,1 receptor binding domain,194897,4168,1 bacterial iron transport,194912,4169,1 epidermal growth factor receptor pathway substrate clone 15,195200,4184,1 eps15 plays a critical role in endocytosis,195200,4184,1 protein interaction domain,195200,4184,1 second EH domain of eps15,195200,4184,1 Sweet-taste inhibitor,195236,4185,1 Binding all-trans-retinoic acid,195253,4186,1 electron transfer,195307,4189,1 Phosphotransferase,195385,4193,1 transcription factors (b-HLH-LZ),195532,4200,1 "Dismutation of superoxide radicals to molecular oxygen and hydrogen peroxide""",195569,4202,1 growth hormone,195613,4204,1 MAP kinase phosphorylation site,195630,4205,1 matrix metalloproteinase (MMP) inhibitor,195834,4214,1 NON-ENZYMATIC PLASMINOGEN-ACTIVATOR,195853,4215,1 transcription factor,195994,4223,1 The exact physiological function of the wild-type protein is not known.,196102,4229,1 antibody,202958,4580,1 "KSI Converts delta-5-3-ketosteroid to delta-4-3-ketosteroid.",196137,4230,1 inhibitor of insect voltage-gated calcium channels,196195,4233,1 Inactivation inhibitor of primate voltage-gated sodium channels,196213,4234,1 "THIII, NADP(H)-binding component (domain III) of proton-translocating transhydrogenase",196246,4236,1 "MinE interacts with the MinC and MinD proteins to ensure correct placement of the division septum in Escherichia coli",196261,4237,1 Xylan binding,196334,4241,1 trypsin inhibitor,196446,4246,1 "The chimeric hybrid duplex is formed during the initiation of HIV-1 reverse transcription, i.e. (-)DNA synthesis.",196463,4247,1 Transcription factor,196482,4248,1 Involved in the nucleotide excision repair,196525,4249,1 Involved in the nucleotide excision repair,196549,4250,1 Transcription factor,196623,4254,1 Transription factor (Mbp1) bound to DNA duplex,196653,4256,1 "MCB12T contains the recognition sequence (ACGCGTCA) for the transcription factor Mbp1. MCB12T is derived from the Mlu 1 cell cycle box (MCB) element found in the promoters of numerous genes involved in DNA sythesis in S. cerevisiae.",196689,4258,1 calcium-regulating hormone,196735,4260,1 calcium-regulating hormone,196755,4261,1 "Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate using NADPH as the coenzyme""",196771,4262,1 chemotactic recognition,196891,4267,1 multimeric matrix-metalloproteinase component,196891,4267,1 small molecule transport,196891,4267,1 recombinase,196942,4269,1 Pathogenesis of amoebiasis,196986,4271,1 Member of the fusion core-complex for synaptoc vesicle exocytosis.,197011,4272,1 Serine Protease,197054,4276,1 Mediates Effects of GH Insulin-Like Metabolic Effects Mitogenic Effects,197077,4278,1 DNA-binding protein,197146,4281,1 gene regulator,197146,4281,1 expression inhibitor,197146,4281,1 fibronectin module,197206,4283,1 Membrane fusion protein,197273,4286,1 Membrane fusion protein,197291,4287,1 EH2 domain of mouse Eps15,197309,4288,1 procapsid assembly,197323,4289,1 antimicrobial activity,197359,4290,1 "The E9 DNase forms the cytotoxic domain of colicin E9 and is located at its C-terminus (the last 134 residues). It acts as an endonuclease and is active on both single- and double-stranded DNA but with undefined specificity. Colicins are plasmid-encoded protein antibiotics produced by, and active against, Eschericia coli and closely related bacteria.",197413,4293,1 transciptional coactivator,197441,4294,1 muscle protein,197456,4295,1 single-strand RNA binding protein,197475,4296,1 single-strand DNA binding protein,197475,4296,1 crucial in viral infection process of HIV-1,197527,4298,1 pyrophosphokinase,197542,4299,1 pyrophosphokinase,197570,4300,1 antifungal activity,197587,4301,1 molecular mechanism unknown,197587,4301,1 "Formation and rearrangement of disulfide bonds",197604,4302,1 light harvesting complex component,197618,4303,1 "SEF2-1 is a basic-Helix-Loop-Helix transcription factor. CaM inhibits the DNA binding of SEF2-1.",197754,4310,1 "Oligomerizes to form the core particle, encapsulating the genome, of the retrovirus HTLV-I.",197777,4311,1 histone acetylated lysine recognition,197795,4312,1 "Disproportionation of superoxide radicals.",197856,4315,1 ion binding subunit of the Na+-translocating F1F0 ATP synthase from Propionigenium modestum,197879,4316,1 Double-stranded RNA binding protein,197913,4317,1 Inhibit RNA splicing,197913,4317,1 "Rubredoxin is a component of the electron transport system and its function is undetermined",197947,4319,1 "Rubredoxin is a component of the electron transport system and its function is undetermined",197986,4320,1 histone acetyltransferase,198010,4321,1 transcription activator,198010,4321,1 crucial in viral infection process of HIV-1,198025,4322,1 deoxyribose 5'-phosphate excision at incised abasic sites (N-terminal domain),198091,4326,1 DNA binding (N-terminal domain),198091,4326,1 DNA polmerization (C-terminal domain),198091,4326,1 "N-TIMP-1 inhibits matrix metalloproteinases-1,-2, & -3 with Ki values less than 2.0 nM.",198107,4327,1 DNA recombinase,198123,4328,1 Reversible reduction of NADP+ by NADH coupled to proton translocation,198139,4329,1 recognizes mhc/antigen complex,198174,4330,1 protease inhibitor,198189,4331,1 "The Glycine Cleavage System catalyses the degradation of Glycine. The Hmet protein shuttles the methylamine group of glycine from the P-protein to the T-protein.",198281,4336,1 "The Glycine Cleavage System catalyses the degradation of glycine The oxidised form of the H-protein is involved in the decarboxylation of glycine",198305,4337,1 "The Glycine Cleavage System catalyses the degradation of glycine. The H protein, a lipoylprotein, plays a central role in the catalytic cycle",198326,4338,1 "EUKARYOTIC RIBOSOMAL PROTEIN, AUTOREGULATION OF ITS SYNTHESIS.",198344,4339,1 ligand binding,198377,4340,1 pheromone,198377,4340,1 "Disproportionation of superoxide radicals.",198409,4341,1 mitochondrial protein,198435,4342,1 copper chaperone,198472,4344,1 "eukaryotic ribosomal protein, autoregulation of its synthesis.",198497,4345,1 THE AUTOREGULATORY BINDING SITE FOR THE YEAST RIBOSOMAL PROTEIN L30.,198518,4346,1 de novo designed protein with nativelike behavior,198536,4347,1 DNA-binding,198555,4348,1 esterolytic antibody,198578,4349,1 potassium channel blocker,203050,4585,1 chitin binding domain of a chitinase,203086,4588,1 PEPTIDE ANTIBIOTIC,203442,4604,1 Biotin carboxyl carrier domain,204301,4666,1 "The E9 DNase forms the cytotoxic domain of colicin E9 and is located at its C-terminus (the last 134 residues). It acts as an endonuclease and is active on both single- and double-stranded DNA but with undefined specificity. Colicins are plasmid-encoded protein antibiotics produced by, and active against, Eschericia coli and closely related bacteria. The cytotoxic activity of colicin E9 is neutralised by the binding of its 9.5 kDa cognate immunity protein, Im9, to the E9 DNase.",198654,4352,1 "The MutY protein, of which the p13_c-terminal_domain is a fragment, functions as a DNA glycosylase (Adenine glycosylase)",198675,4353,1 binds maltose and related sugars,198689,4354,1 transcription regulatory protein,198706,4355,1 human HOX cofactor,198725,4357,1 human HOX cofactor,198746,4358,1 human HOX cofactor,198767,4359,1 central nervous system formation,198970,4368,1 embryodevelopment,198970,4368,1 transcription factor,198970,4368,1 ribosomal protein,198999,4369,1 anti-tumor agent,199055,4371,1 cytotoxic protein,199055,4371,1 ribonuclease,199055,4371,1 peptide binding,199137,4376,1 protein folding and unfolding,199137,4376,1 protein recognition,199137,4376,1 "Frequenin is a Ca2+-binding protein involved in the transduction of nerve stimuli trough synaptic nerve endings where it potentiates neuromitter release",199177,4378,1 calcium-dependent cell adhesion molecule,199236,4380,1 electron transfer protein,199272,4382,1 "Retroviral Capsid proteins oligomerize to form the core particle, that encapsulates the RNA viral genome.",199304,4384,1 elongation factor,199325,4385,1 guanine nucleotide exchange factor,199325,4385,1 transcription regulator,199388,4388,1 disassemble post termination complex during protein biosynthesis,199410,4389,1 chemoattractant for eosinophils,199440,4390,1 Post synaptic neurotoxin,199456,4391,1 "-bacterial translation initiation factor -promotes dissociation of ribosomal subunits -destabilizes non-cognate initiation ternary complexes (tRNA/mRNA/30S)",199501,4394,1 binds to 5S rRNA in the 50S ribosomal subunit,199516,4395,1 anticoagulant,199535,4396,1 protease inhibitor,199535,4396,1 regulates skeletal muscle contraction in a calcium dependent fashion,199646,4401,1 involved in prion disease,199678,4402,1 "J chaperone, supports Py DNA replication and transformation by the tumor antigens. Stimulates the ATPase activity of hsp70 class chaperones in vitro.",199699,4403,1 alpha-amylase inhibitor,199727,4404,1 Regulator of G protein signaling,199779,4407,1 lectin,199851,4410,1 TGF-beta3 is citokine that regulate proliferation and differentiation of many different cell types.,199873,4411,1 electron transfer,199944,4414,1 CTII damage cells by membrane perturbation.,200036,4418,1 CTII damage cells by membrane perturbation.,200062,4419,1 neurotoxin,200097,4420,1 Protease inhibitor,200128,4422,1 "DNA-binding domain (putative) protein-protein recognition motif",200147,4423,1 "Protein L7/L12 is very important for the protein synthesis in ribosome. Two L7/L12 dimers are associated with 23S rRNA via protein L10 near from the A-site of ribosome. The following model of the L7/L12 dimer was derived: two N-terminal parts (Ser1-Ser33)*2 form a symmetrical four-helical bundle, and two independent identical globular C-terminal domains (Thr52-Lys120) are connected to the bundle via highly mobile hinge regions. The N-domain of the L7/L12 dimer is responsible for its incorporation into the ribosome. The C-domains of the L7/L12 dimer are crucial for inducing GTPase activity in EF-Tu and EF-G elongation factors.",200292,4429,1 regulatory protein,200349,4431,1 Primary inhibitory receptors in the spinal cord,200379,4432,1 Primary inhibitory receptors in the spinal cord,200401,4433,1 See SWISS-PROT P22307,200531,4438,1 auxiliary domain in RecQ helicases,200673,4445,1 disulfide-containing redox protein,200714,4446,1 nucelotide phosphohydrolase,200759,4448,1 "ice growth inhibitor thermal hysteresis protein",200791,4449,1 regulation of caspase activated DNase activity,200817,4451,1 antifreeze activity,200847,4452,1 Components of Z-disk in muscle sarcomere,200873,4453,1 components of Z-disk in muscle sarcomere,200907,4454,1 cell-cell adhesion,200970,4457,1 "metal storage (assumed) metal distribution (assumed) metal detoxification (assumed)",201080,4462,1 "The RAS-binding domain of the protein kinase Byr2 is studied",201105,4463,1 Unknown. Causes 'stiff tail' syndrome when injected in mice,201135,4464,1 Electron transfer,201176,4466,1 "methyl-CpG-binding protein, attachment region binding protein",201205,4467,1 Unknown. Causes 'stiff tail' syndrome when injected in mice,201231,4468,1 Unknown. Causes 'stiff tail' syndrome when injected in mice,201247,4469,1 sulfur carrier during thiamin biosynthesis in E.Coli.,201274,4470,1 electron-transfer mediator in bacterial respiratory chain,201297,4471,1 Chemotaxis response regulator,201330,4472,1 substrate binding domain of a protease,201831,4510,1 "Domain is responsible for docking the glycosidic subunits (in this case CelS) to the cohesin domains of CipA from Clostridium thermocellum, thus assembling them into the multiprotein complex (cellulosome)",201973,4524,1 antimicrobial peptide,202249,4552,1 reductase,202299,4554,1 an effector protein in Toluene-4-monooxygenase complex,202460,4560,1 hydrolase,202516,4562,1 conjugatin enzyme in ubiquitin system,202643,4567,1 oxygen storage,202670,4568,1 dna-binding,202705,4570,1 rnase,202705,4570,1 RNA polymerase subunit,202722,4571,1 ribosomal protein,202840,4577,1 small subunit assembly,202840,4577,1 binds mRNA,202840,4577,1 carboxylase,204301,4666,1 "peptidylprolyl cis-trans isomerase chaperone",204324,4668,1 Prolyl cis/trans isomerase,204373,4670,1 lipid binding protein,204409,4673,1 "subunit of chaperone DnaJ, exact function of subunit unknown thought to bind to unfolded proteins and thought to mediate interaction of DnaJ with DnaK",204473,4677,1 matrix metalloproteinase,204508,4679,1 retinol transport,204553,4681,1 retinol transport,204575,4682,1 Tyrosine Binding Domain,204598,4683,1 Metal detoxification,204616,4684,1 Metal regulation,204616,4684,1 Metal donation,204616,4684,1 insecticidal neurotoxin,204634,4685,1 RNA-binding protein,204682,4688,1 oxygen storage,204778,4695,1 toxin,204795,4696,1 Cdc42: small GTPase involved in cytoskeletal regulation,204873,4700,1 PAK: Ser/Thr kinase Cdc42 binding,204873,4700,1 inhibit DNA binding of p53,204916,4702,1 "hydrolyzes beta-1,4 linkages in xylan",204960,4704,1 Binding to amorphous cellulose and soluble cellulosic derivatives,204976,4706,1 "transcription factor post-trancriptional regulator (putative)",205002,4707,1 "transcription factor post-trancriptional regulator (putative)",205029,4708,1 "transcription factor post-trancriptional regulator (putative)",205058,4709,1 "transcription factor post-trancriptional regulator (putative)",205099,4710,1 mitogen,205145,4712,1 endocytosis,205215,4716,1 molecular chaperone,205215,4716,1 bacterial cell division protein,205233,4717,1 replication terminator,205247,4718,1 phosphoryl transfer,205350,4722,1 "metal detoxification Cu-regulation",205410,4725,1 ribosomal protein,205449,4727,1 anticoagulant,205482,4728,1 anticoagulant,205497,4729,1 DNA binding protein,205553,4732,1 chromatin-associated protein,205553,4732,1 chromatin-associated protein,205573,4733,1 DNA binding protein,205573,4733,1 "DNA binding protein chromatin-associated protein",205595,4734,1 transcriptional antitermination,205661,4737,1 chitin binding domain of a chitinase,205811,4742,1 electron transfer,205840,4743,1 electron transfer,205869,4744,1 cysteine proteinase inhibitor,205991,4748,1 DNA binding domain putative ATP binding or hydrolysis site,206092,4752,1 "metal detoxification Cu-regulation",206157,4754,1 electron transfer protein,206240,4759,1 enhancer-binding protein,206311,4762,1 transcriptional regulation,206311,4762,1 enhancer-binding protein,206332,4763,1 transcriptional regulation,206332,4763,1 electron transfer,206395,4767,1 peptidyl prolyl cis/trans isomerase,206414,4768,1 involved in hyphal transformation,206460,4770,1 RNA binding protein,206497,4772,1 major surface antigen,206516,4773,1 PHOSPHATE GROUP TRANSLOCATION IN CARBOHYDRATE TRANSPORT,206537,4774,1 electron-transfer mediator in bacterial respiratory chain,206585,4777,1 involved in hyphal transformation,206619,4778,1 eukaryotic signal transduction,206637,4779,1 "Major splice donor site Viral genome packaging",206673,4780,1 Major splice donor site,206701,4781,1 Viral genome packaging site,206701,4781,1 Calcium-dependent D-galactose binding,206726,4782,1 Bleomycin resistance by its sequestration,206769,4785,1 Phleomycin resistance by its sequestration,206769,4785,1 Tallysomycin resistance by its sequestration,206769,4785,1 Bleomycin resistance by its sequestration,206785,4786,1 Phleomycin resistance by its sequestration,206785,4786,1 Tallysomycin resistance by its sequestration,206785,4786,1 parasite invasion of erythrocytes,206808,4787,1 protein binding domain,206837,4788,1 "TAZ2 domain is involved in protein-protein recognition CBP is a transcriptional activator protein",206869,4789,1 NTPase,206931,4791,1 RNA helicase,206931,4791,1 antitoxin,206956,4792,1 plasmid stabilization,206956,4792,1 DNA-binding,206956,4792,1 autoregulation,206956,4792,1 possible signal transduction protein,206981,4793,1 Actin binding protein,207010,4794,1 Actin binding protein,207029,4795,1 toxin,207079,4797,1 cytolysin,207079,4797,1 activator of phosphatidylinositol 4-kinase,207095,4798,1 The isolated c domain is an electron carrier,207158,4800,1 "In cytochrome cd1 nitrite reductase, the c domain functions as the port of entry of electrons.",207158,4800,1 The isolated c domain is an electron carrier,207183,4801,1 "In cytochrome cd1 nitrite reductase, the c domain functions as the port of entry of electrons.",207183,4801,1 oligomerisation of H-NS,207210,4802,1 Transcriptional repressor,207461,4813,1 lipoprotein binding,207481,4814,1 protein disulfide oxidoreductase,207541,4817,1 Regulatory domain involved in the inactivation of the MAP kinase ERK2,207567,4818,1 ribonuclease,207681,4825,1 antitumor,207681,4825,1 cytotoxic protein,207681,4825,1 cysteine proteinase inhibitor,207707,4827,1 cysteine proteinase inhibitor,207725,4828,1 DNA-binding protein,207743,4829,1 Growth factor,207808,4832,1 Antifungal protein,207825,4833,1 Chitin-binding protein,207825,4833,1 peptide deformylase,207856,4834,1 restriction site,207881,4835,1 hydrolase,207898,4836,1 retroviral protease,207964,4839,1 transcriptional regulator,208015,4841,1 regulation of gastrointestinal function,208036,4842,1 regulation of blood pressure,208036,4842,1 regulation of feeding behavior,208036,4842,1 enolpyruvyltransfer from PEP to Shikimate-3-phosphate to form enolpyruvyl shikimate-3-phosphate,208134,4848,1 Pheromone-binding protein,208149,4849,1 Neurotoxin with binding properties to voltage-gated sodium channels,208242,4853,1 "enolpyruvyl transfer from PEP to Shikimate-3-phosphate to form enolpyruvyl shikimate-3-phosphate",208261,4854,1 "The species discussed is a stable mimick of the (14-38, 30-51) folding intermediate in BPTI folding",208289,4855,1 calcium-binding,208311,4856,1 zinc-binding,208311,4856,1 histidine-containing phosphotransfer,208330,4857,1 neurohormone,208423,4862,1 neurotransmitter,208423,4862,1 mediates transfer between E1 and E3 components of ubiquitination pathways,208491,4866,1 promoter DNA recognition factor,208584,4870,1 Tumor suppressor,208616,4871,1 "The species discussed is a stable mimick of the (30-51) folding intermediate in BPTI folding",208666,4873,1 transcriptional regulator,208695,4874,1 "The species discussed is a stable mimick of the (30-51, 5-14) folding intermediate in BPTI folding""",208717,4875,1 "The species discussed is a stable mimick of the (30-51, 5-38) folding intermediate in BPTI folding",208753,4877,1 Transpeptidase,208790,4879,1 holoflavodoxin is an electron transfer protein,208868,4881,1 adaptor protein,208917,4884,1 binds to ILK and Nck-2 (biological data),208917,4884,1 NTPase,208946,4885,1 holoflavodoxin is an electron transfer protein,208976,4886,1 binds proline rich motifs,209007,4888,1 binds proline rich motifs,209021,4889,1 Ribonuclease,209114,4893,1 antitumor,209114,4893,1 cytotoxic protein,209114,4893,1 response-regulator protein,209164,4896,1 bacterial adhesin,209194,4897,1 Involved in splicing,209256,4899,1 Mutations cause SMA,209256,4899,1 Sm protein interaction,209256,4899,1 xylan binding module from a xylanase,209303,4900,1 F1 ATPase inhibitor,209406,4906,1 amphipathic intrinsic membrane protein,209437,4907,1 modulator of the calcium pump in sarcoplasmic reticulum,209437,4907,1 lectin,209482,4909,1 putative serine proteinase inhibitor,209517,4910,1 multifunctional regulatory protein,209535,4911,1 multifunctional regulatory protein,209562,4912,1 Chemokine receptor Inhibitor,209598,4914,1 Adenylate cyclase activating (cAMP),209641,4916,1 Pilus structural protein,209684,4918,1 Twitching motility,209684,4918,1 Bacteria phage absorption,209684,4918,1 "Neurotoxin Sodium channel inhibitor",209761,4921,1 HIV inactivating-protein,209876,4927,1 Component of cytoplasmic and flagellar dynein. Involved in motor-cargo interactions,209929,4929,1 growth factor,209960,4930,1 motogen,209960,4930,1 multifunctional regulatory protein,209975,4931,1 motogen,210015,4933,1 growth factor,210015,4933,1 A protein component of the signal recognition particle,210066,4935,1 "OmpX belongs to a family of highly conserved bacterial proteins that promote bacterial adhesion to mammalian cells and entry into them. Moreover, these proteins have a role in the resistance against attack by the human complement system.",210093,4936,1 Hairpinless mutant is inactive,210113,4937,1 Native toxin inhibits insect calcium channels,210113,4937,1 transcription factor,210143,4939,1 Honeybee pheromone carrier protein,210180,4940,1 DNA-repair enzyme,210198,4941,1 antitumor,210224,4942,1 cytotoxic protein,210224,4942,1 ribonuclease,210224,4942,1 bacteriolytic function,210242,4943,1 hydrolysis and transglycosylation,210242,4943,1 arsenate reductase,210265,4944,1 neurotoxin,210348,4948,1 HIV accessory protein,210382,4950,1 membrane anchoring domain,210382,4950,1 HIV accessory protein,210403,4951,1 membrane anchoring domain,210403,4951,1 PPIase,210439,4953,1 synthesis of riboflavin in bacteria,210472,4954,1 activator of T4 phage middle-mode gene expression,210521,4957,1 electron transport chain,210610,4960,1 bacterial respiration,210610,4960,1 defeats the non-specific immune response of host organisms,210630,4961,1 "Nedd4 is a ubiquitin protein ligase WW domains of Nedd4 bind PY motif-containing regions in target molecules, including ENaC. ENaC is an ameloride-sensitive sodium channel located on the apical membrane of polarized epithelia. Nedd4 WW domains bind ENaC PY motifs and Nedd4 is a suppressor of ENaC that regukates channel stability at the plasma membrane, likely by ubiquitination.",210659,4963,1 ribonuclease,210710,4964,1 ribosomal protein,210738,4965,1 binds RNA,210738,4965,1 part of the GTPase center,210738,4965,1 depolarization of muscular cell,210775,4966,1 hemolysis,210775,4966,1 heparin binding protien,210775,4966,1 membrane binding protein,210775,4966,1 protein with one bound water,210775,4966,1 Aspartic protease,210790,4967,1 antibody,210823,4969,1 phospho-carrier protein,210965,4972,1 inhibitor of von Willebrand factor-dependent platelet adhesion to collagen,210990,4973,1 antibacterial,211045,4976,1 antifungal,211045,4976,1 lipid transfer protein,211069,4977,1 domain acts as a signal to induce aggregation (clustering) of acetylcholine receptors on the postynaptic membrane (muscle) of neuromuscular junctions.,211103,4978,1 pheromone,211131,4979,1 ribonuclease,211168,4980,1 lipid binding protein,211190,4981,1 Ca-binding protein,211219,4982,1 NADPH dependent sulfite reduction,211290,4985,1 electron transfer,211290,4985,1 neurotoxin,211380,4988,1 catalyse cellular redox reactions,211444,4991,1 T4moC is required for electron transfer between the oxidoreductase and diiron hydroxylase components of toluene 4-monooxygenase,211458,4992,1 antibiotic,211486,4993,1 channel-former,211486,4993,1 Muscle contraction regulatory protein bound to Ca2+ sensitizer,211510,4994,1 actin thin-filament regulation,211540,4995,1 conserved archeal protein,211582,4996,1 unknown function,211582,4996,1 Peptide hormone,211600,4997,1 chaperone,211644,4999,1 negative strand RNA virus polymerase cofactor,211644,4999,1 nucleocapsid binding domain,211644,4999,1 phosphoprotein,211644,4999,1 MAP Kinase Phosphatase,211709,5000,1 Catalytic domain involved in the inactivation of the MAP kinase ERK2,211709,5000,1 Light-driven proton pump,211837,50009,1 "The G-patch region of Spp2 binds to the DEAH-box ATPase Prp2, and both proteins together are essential for promoting the transition from the Bact to the catalytically active B* spliceosome.",211916,50014,1 Catalyzes the interconversion of ribulose-5-phosphate and ribose-5-phosphate,212035,50025,1 Natural Antimicrobial Compound,212064,50027,1 electron transfer protein,212093,5003,1 electron transfer protein,212164,5005,1 toxin,212186,5006,1 catalytic RNA molecule,212201,5007,1 ubiquitylation,212319,50084,1 Regulation,212400,50093,1 Template-directed nucleotidyl transferase,212494,5010,1 electron transfer,212671,5011,1 gelatin binding region,212796,5012,1 DNA replication and repair,212829,50121,1 Ubiquitin protein ligase,212975,5013,1 potassium channel,213060,50135,1 myosin binding protein,213103,5014,1 muscle protein,213103,5014,1 regulatory protein,213103,5014,1 The full length protein is an electroneutral antiporter for K+ and H+ ions across the inner membrane.,213303,50166,1 circadian regulator,213581,5019,1 transcriptional activator,213581,5019,1 "The assembly performes enzymatic reaction - hydrolysis of inorganic pyrophosphate with formation of two inorganic orthophosphate ions. It is constitutive enzyme of the host organism - Mycobacterium tuberculosis. Hydrolyzing inorganic pyrophosphate - the product of many biochemical processes - inorganic pyrophosphatase shifts the chemical equilibrium of these processes to the products and thus gives thermodynamical push to main biochemical cascades of the host organism.",213849,50212,1 Mitochondrial intermembrane space protein chaperoning,213874,50213,1 kinetochore protein,213908,50215,1 microtubule-binding,213908,50215,1 FusB binding to EF-G confers resistance to the antibiotic fusidic acid that otherwise inhibits EF-G.,213992,50220,1 Translocation factor for bacterial protein synthesis,214010,50221,1 kinetochore protein,214025,50228,1 microtubule-binding,214025,50228,1 kinetochore protein,214043,50229,1 microtubule-binding,214043,50229,1 PKIa binds PKA-C and inhibits the enzyme function,214091,50238,1 PKIa mediates the nuclear exportation of PKA-C by interaction with CRM1/RanGTP complex,214091,50238,1 PKIa binds PKA-C and inhibits the enzyme function,214166,50243,1 PKIa mediates the nuclear exportation of PKA-C by interaction with CRM1/RanGTP complex,214166,50243,1 Protein translation initiation,214306,50250,1 "Inhibition of SARS-CoV-2 polyprotein (pp1a, pp1ab) processing",214452,50262,1 trypsin inhibitor,214685,5028,1 neurotoxin,214702,5029,1 Conversion of chorismic acid to prephenic acid,214716,50297,1 General Odorant-Binding Protein,214770,5030,1 iron uptake,215058,50332,1 solute binding for ABC transporter,215058,50332,1 iron uptake,215074,50333,1 solute binding for ABC transporter,215074,50333,1 "Subunit in betacoronavirus replication/transcription complexes. RNA-binding, DNA-binding.",215094,50334,1 Required for self assembly of major ampullate spidroin 2,215390,50353,1 N-type calcium channel blocker,215573,5039,1 Chemokine,215753,5042,1 cell adhesion molecule,215790,5044,1 PARylation,215813,50454,1 Element in internal ribosome entry site of hepatitis C RNA,215951,5046,1 lipid binding,216065,5048,1 retinoid carrier,216065,5048,1 receptor for type I interferons,216088,5049,1 protease inhibitor,216117,5050,1 nucleotide phosphohydrolase,216218,5054,1 RNA binding protein,216252,5055,1 serine protease inhibitor,216280,5056,1 Ab(1-40) is associated with Alzheimer disease,216299,5057,1 GABA-A receptor targeting,216313,5058,1 Inhibits survival and neurite formation of cortical neurons in vitro,216508,5066,1 "Binds heavy metals, found bound to zinc and copper ions as isolated from brain",216508,5066,1 Hydrolase(O-Glycosyl),216548,5068,1 Hydrolase(O-Glycosyl),216568,5069,1 tyrosyl-tRNA synthetase,216601,5070,1 anticodon-arm binding domain,216601,5070,1 collagen binding,224827,5456,1 interferon resistance/eIF2alpha structural homolog,216763,5077,1 lipoyl acid bearing,216797,5078,1 electron-transfer mediator in bacterial respiratory chain,216822,5079,1 electron-transfer mediator in bacterial respiratory chain,216865,5080,1 hemophore,216894,5081,1 K+-channel blocker,216911,5082,1 fatty acid carrier,216926,5083,1 lipid binding protein,216926,5083,1 putative electron transfer,217002,5086,1 putative electron transfer,217021,5087,1 putative electron transfer,217039,5088,1 putative electron transfer,217058,5089,1 inactivation of BK channels,217127,5092,1 cold-shock adaptation protein from the bacterium Escherichia Coli,217145,5093,1 RbfA is probably involved in ribosome maturation and/or translation initiation,217145,5093,1 neurotoxin,217225,5097,1 "N-TIMP-1 inhibits the enzymatic activity of matrix metalloproteinases-1,-2, &-3 with Ki values less than 2.0 nM.",217263,5099,1 "Ldb1 is a nuclear protein that binds to a number of nuclear LIM-domain containing proteins. It binds to LMO2 and this binary complex is thought to take part in higher order transcriptional complexes.",217308,5100,1 "LMO2 (otherwise known as rhombotin-2) is an essential haematopoietic transcription factor. Its overexpression in T cells causes the onset of Acute T-cell Lymphoblastic Leukemia (T-ALL).",217308,5100,1 Calcium-binding protein,217391,5103,1 substrate binding,217457,5107,1 integrin antagonist,217704,5117,1 ion-binding subunit of the Na+-translocating F1F0 ATP synthase from Propionigenium modestum,217729,5119,1 metastasis inducer,217894,5127,1 signal transduction,217985,5131,1 protein:protein interaction,217985,5131,1 protein tyrosine phosphatase,217985,5131,1 trypsin/chymotrypsin inhibitor,218021,5132,1 trypsin/chymotrypsin inhibitor,218034,5133,1 sensory domain,218206,5141,1 metal detoxification,218300,5147,1 metal regulation,218300,5147,1 "N-TIMP-1 inhibits the enzymatic activity of matrix metalloproteinases-1,-2, &-3 with Ki values less than 2.0 nM",218456,5153,1 "N-TIMP-1 inhibits the enzymatic activity of matrix metalloproteinases-1,-2, &-3 with Ki values less than 2.0 nM",218482,5154,1 cofactor of the p97-regulated t-t-SNARE disassembly,218501,5155,1 Calcium-binding protein of the EF-hand family,218540,5156,1 A member of the calbindin D28k subgroup,218540,5156,1 lowers melting point of water,218559,5157,1 antimicrobial,218651,5160,1 hypothetical,218739,5165,1 hemolysin expression modulating protein,218758,5166,1 electron transfer,218880,5172,1 Trypsin inhibitor,218946,5176,1 modulates actin polymerization,218967,5177,1 Transcriptional activation,219027,5180,1 Xylan binding module from a xylanase,219061,5181,1 Scorpion toxin BeKm is specific blocker of hERG1 potassium channels.,219137,5184,1 calcium-binding protein,219234,5189,1 "Polypeptide mPrP(143-158) contains the segment of helix 1 of mouse prion protein. This helix has been implicated in various stages of hypothetical pathways to prion pathology based on the protein-only idea, including functions as a binding site for PrPSc in infectious prion diseases, and as part of the peptide sequence involved in the conformation change leading from PrPC to PrPSc.",219367,5197,1 Elicitor of plant defense responses,219406,5199,1 H+ ATPase stimulator,219406,5199,1 facilitate the KSR protein scaffold function,219494,5203,1 calcium modulatory protein,219559,5206,1 calcium-binding protein,219588,5207,1 DNA polmerization (C-terminal domain),219609,5208,1 DNA binding (N-terminal domain),219609,5208,1 deoxyribose 5'-phosphate excision at incised abasic sites (N-terminal domain),219609,5208,1 DNA polmerization (C-terminal domain),219634,5209,1 DNA binding (N-terminal domain),219634,5209,1 deoxyribose 5'-phosphate excision at incised abasic sites (N-terminal domain),219634,5209,1 "This molecule (sTva47) represent only a portion of the extracellular domain of the receptor called Tva that binds to the envelope glycoprotein of subgroup A Avian Leukosis and Sarcoma virus.",219658,5210,1 copper-transport in Bacillus subtilis,219724,5213,1 Binds to bubble DNA with minimum 6 unpaired bases in the middle,219814,5217,1 Non-Sequence Specific DNA binding,219814,5217,1 Participates in the 5- incision of the DNA in Nuclear Excision Repair,219814,5217,1 "ATP-dependent breakage, passage and rejoining of double-stranded DNA",219835,5218,1 DNA glycosylase,219850,5219,1 AP lyase,219850,5219,1 deoxyribophosphodiesterase,219850,5219,1 protein of the nuclear lamina,219966,5224,1 cis-trans peptidyl prolyl isomerase,219991,5225,1 histone-like DNA binding protein,220027,5226,1 coactivator of nuclear hormone receptor mediated transcription,220079,5228,1 matrix metalloproteinase,220122,5231,1 "Binds single-stranded telomeric overhang with high affinity and sequence specificity.",220150,5232,1 hexamerisation ATP/Tyrosine binding,220206,5234,1 "N-terminal tandem inactivation domain of the voltage-gated potassium channel Kv1.4 (RCK4).",220241,5236,1 electron transport,220298,5239,1 disulfide oxidoreductase,220317,5240,1 disulfide oxidoreductase,220345,5241,1 protease inhibitor,220370,5242,1 DNA repair,220406,5244,1 hormone,220462,5246,1 glucose metabolism,220462,5246,1 disease mutation,220462,5246,1 diabetes,220462,5246,1 metastasis inducer,220486,5247,1 possible electron transfer protein,220535,5249,1 transcriptional antiterminator,220558,5250,1 possible electron transfer protein,220709,5260,1 nuclease inhibitor,220732,5261,1 antimicrobial protein,220780,5264,1 antibacterial peptide,220800,5265,1 possible electron transfer protein,220934,5271,1 protease inhibitor,220961,5272,1 protease inhibitor,220989,5273,1 protease inhibitor,221003,5274,1 sialic acid binding protein,221024,5275,1 viral cell-attachment protein,221024,5275,1 lectin,221024,5275,1 DNA binding,221146,5280,1 fatty acid carrier,221241,5284,1 fatty acid carrier,221262,5285,1 "Grb7:adapter protein, binds RTKs, up-regulated in subset of breast and esophageal cancers.",221321,5288,1 "Downstream eff. of RTK cell signaling, upreg. in breast and esophageal cancer, involv. in cell spreading and migr.",221321,5288,1 Translocation through biological membranes.,221344,5289,1 "Transportation of covalently linked oligonucleotides and oligopeptides through biological membranes.",221344,5289,1 Translocation through biological membranes.,221363,5290,1 "Transportation of covalently linked oligonucleotides and oligopeptides through biological membranes.",221363,5290,1 Translocation through biological membranes.,221380,5291,1 "Transportation of covalently linked oligonucleotides and oligopeptides through biological membranes.",221380,5291,1 Barnase inhibitor,221417,5293,1 Elicits intense sweet-tasting response,221473,5295,1 Initiation of geminiviral replication (nuclease),221503,5297,1 Termination of replication (ligase),221503,5297,1 genome replication specificity determinant,221503,5297,1 Transcriptional autorepressor,221503,5297,1 Transcriptional Activator,221503,5297,1 peptidyl-prolyl cis/trans isomerase,221542,5298,1 peptidyl-prolyl cis-trans isomerase,221752,5305,1 oxidoreductase,221816,5308,1 Binds cell surface receptors and participates in intracellular signalling.,221884,5310,1 pathogen effector protein,221904,5311,1 kinase regulator,221904,5311,1 Recognition of initiation codon,221933,5312,1 Interactions with mRNA,221933,5312,1 GAP for aIF2,221933,5312,1 signalling adapter,221969,5314,1 Ribosome associated factor,221992,5315,1 Binds cell surface receptors and participates in intracellular signalling.,222071,5318,1 lipid binding,222086,5319,1 retinoid carrier,222086,5319,1 fatty acid carrier,222125,5320,1 disintegrin,222176,5322,1 neurotoxin,222176,5322,1 antifreeze protein,222191,5323,1 lipid transfer,222233,5325,1 BRCT is mostly found in cell cycle regulation and DNA repair proteins,222305,5328,1 BRCT is probably a protein-protein interaction domain,222305,5328,1 Transcriptional activator,222305,5328,1 lipid binding,222344,5330,1 retinoid carrier,222344,5330,1 lipid binding,222369,5331,1 retinoid carrier,222369,5331,1 rhodopsin kinase inhibitor,222396,5332,1 unknown function zinc finger protein,222467,5335,1 electron-transfer protein,222487,5337,1 an intracellular amplifier of apoptotic signaling,222546,5340,1 Initiation of geminiviral replication (nuclease),222559,5341,1 Termination of replication (ligase),222559,5341,1 genome replication specificity determinant,222559,5341,1 Transcriptional autorepressor,222559,5341,1 Transcriptional Activator,222559,5341,1 Protein component of the antitumour antibiotic Neocarzinostatin,222614,5343,1 protein component of the antitumour antibiotic Neocarzinostatin,222643,5344,1 regulation of the genes located in lac operon,222662,5345,1 platelet aggregation inhibitor,222685,5346,1 Catalyzes the cleavage of the RNA portion of a DNA/RNA hybrid,222702,5347,1 transcription factor,222748,5349,1 protein tyrosine phosphatase,222767,5350,1 "endo-1,4-beta-D-xylan-hydrolysis",222804,5352,1 molecular chaperone,222866,5355,1 heat shock protein,222866,5355,1 ATPase,222866,5355,1 Transcriptional antiterminator,222992,5362,1 transcription factor DNA binding domain,223018,5363,1 nucleoporin binding domain,223056,5364,1 transcriptional factor,223075,5365,1 pre-mRNA splicing,223208,5371,1 electron transfer,223223,5372,1 cell apoptosis,223223,5372,1 signal transduction in the visual system,223302,5376,1 regulation of gastrointestinal function,223376,5379,1 "cTnC regulatory domain and cTnI help regulate muscle contraction by binding Ca2+. Bepridil is a Ca sensitizer.",223482,5386,1 adaptor protein,223539,5388,1 cold shock response protein,223565,5389,1 translation inhibitor,223565,5389,1 Oligomerization Domain,223609,5390,1 Bacterial Chromatin Structuring,223609,5390,1 "HYDROLYSIS OF THE DEOXYRIBOSE N-GLYCOSIDIC BOND TO EXCISE 3-METHYLADENINE FROM THE DAMAGED DNA POLYMER FORMED BY ALKYLATION LESIONS.",223805,5398,1 PNT domain / SAM domain,223825,5399,1 PNT domain / SAM domain,223881,5401,1 transcriptional regulation,223929,5403,1 translational regulation,223929,5403,1 removal of N-terminal formyl group from methionine,223945,5404,1 electron transfer,223997,5406,1 RNA binding,224083,5409,1 peptide hormone,224787,5454,1 phosphatase,224804,5455,1 transcription factor,224841,5457,1 dissociates protein translational posttermination complex,224861,5458,1 tyrosine kinase,224920,5461,1 signaling protein,224970,5463,1 DNA binding protein,224989,5464,1 "Acts as an adapter protein of the FYN kinase and the SH2-domain-containing leucocyte protein-76 (SLP76). ADAP is involved in the signalling cascades leading to the production of interleukin 2. Regulates integrin activity.",225053,5467,1 hydrolase,225079,5468,1 protein tyrosine phosphatase,225199,5474,1 ubiquitin-like conjugation,225386,5481,1 microtubule binding domain,225408,5482,1 component of 50S ribosome subunit,225497,5485,1 antimicrobial peptide,225524,5486,1 antimicrobial peptide,225546,5487,1 antimicrobial peptide,225567,5488,1 antimicrobial peptide,225585,5489,1 antifungal peptide,225628,5491,1 thiol-disulfide reductase,225742,5497,1 signal transduction,225760,5498,1 ubiquitin-protein ligase,225809,5500,1 kinase,225884,5504,1 regulator of complement activation,225950,5506,1 regulation of the actin cytoskeleton,226039,5511,1 gene expression,226039,5511,1 cell proliferation,226039,5511,1 cell adhesion,226039,5511,1 apoptosis,226039,5511,1 Ribosomal protein 50S ribosomal subunit,226084,5513,1 Transcription regulatory protein,226180,5517,1 involved in cell-cycle regulation,226180,5517,1 Putative glycoprotein-binding region of a bacterial toxin,226389,5524,1 "surface constituent of plasma lipoproteins, activator for lipoprotein lipase (LPL) lipid, transport in blood",226602,5534,1 excisionase,226733,5539,1 fatty acid carrier,226786,5541,1 Calcium-binding protein,226843,5544,1 insulin-like growth factor inhibitor,226863,5545,1 extracellular cysteine protease,226878,5547,1 regulation of gastrointestinal function,226925,5548,1 neurohormone,226960,5549,1 neurotransmitter,226960,5549,1 regulation of gastrointestinal function,227000,5550,1 regulation of blood pressure,227000,5550,1 regulation of feeding behavior,227000,5550,1 Kazal-type,227033,5551,1 temporary serine proteinase inhibitor,227033,5551,1 DNA binding domain,227181,5558,1 required for active partition of bacterial plasmids,227308,5563,1 phosphoprotein binding domain,227322,5564,1 immunoglobulin-binding domain of streptococcal protein,227419,5569,1 hypothetical Nudix protein,227546,5570,1 ice growth inhibition,227596,5572,1 ice growth inhibition,227610,5573,1 Stimulator of extra-vascular smooth muscle,227622,5574,1 Vasodialator,227622,5574,1 Vasodialator,227639,5575,1 retinol transporter,227698,5578,1 retinol transporter,227728,5579,1 Human cathepsin L inhibitor,227835,5583,1 Electron-transfer protein,227857,5584,1 neuronal nACh receptor antagonist,227881,5585,1 DNA binding protein as homodimer,228013,5590,1 muscle assembly and regulation,228039,5591,1 DNA-binding domain,228068,5592,1 zinc-binding domain,228068,5592,1 Interacts with glucocorticoid receptor,228068,5592,1 DNA-binding domain,228093,5593,1 full-length protein activates parvovirus nickase NS1 protein,228093,5593,1 zinc-binding domain,228093,5593,1 copper(I) binding protein,228145,5595,1 electron transfer,228332,5600,1 electron transfer,228366,5601,1 "zinc, cadmium transport ATPase",228448,5604,1 ion channel-lining peptide,228525,5607,1 actin regulatory protein,228605,5610,1 response regulator,228701,5615,1 cross-intron bridging protein,228718,5616,1 protease inhibitor,228745,5617,1 peptide methionine sulfoxide reductase msrB,228781,5619,1 ribosomal protein S28E,228818,5620,1 Thioredoxin-like,228881,5622,1 essential for virus assembly,228902,5623,1 Deacetylates the Lipid A precursor UDP-3-O-acyl-N-acetylglucosamine,229006,5627,1 A ribosomal protein.,229432,5650,1 A chaperone docking site on the ribosome.,229432,5650,1 Anchors the SRP to the ribosome.,229432,5650,1 HERG K+ channel inhibitor,229488,5652,1 molt-inhibiting hormone,229505,5653,1 hydrolase,229636,5659,1 electron transfer,229662,5660,1 cell apoptosis,229662,5660,1 acyl carrier protein,229739,5664,1 molecular chaperone,229760,5665,1 "HYDROLYSIS OF DEOXYRIBOSE N-GLYCOSIDIC BOND TO EXCISE 3-METHYLADENINE FROM DAMAGED DNA POLYMER FORMED BY ALKYLATION LESIONS",229823,5668,1 ubiquitin binding domain,229867,5669,1 sodium channel inhibitor,229996,5674,1 potassium channel blocker,230033,5676,1 toxin,230033,5676,1 binds paxillin,230051,5677,1 binds grb2,230051,5677,1 binds talin,230051,5677,1 targets FAK to focal adhesions,230051,5677,1 carbohydrate binding,230082,5679,1 Secreted antigenic proteins of unknown function,230126,5680,1 ribosomal protein of unknown function,230171,5682,1 CTD Phosphatase,230225,5685,1 Prosequence of cathelicidin antibacterial peptides,230309,5688,1 cobrotoxin,230367,5690,1 neurotoxin,230367,5690,1 ribosomal protein,230395,5691,1 protein recognition domain from an adaptor protein,230448,5692,1 signal transduction,230471,5693,1 Alpha-actinin-2 binding protein,230533,5696,1 components of Z-disk in muscle sarcomere,230563,5697,1 peptide binding domain,230583,5698,1 tumor suppressor,230628,5700,1 A non-Dbl guanine nucleotide exchange factor for the Rho GTPases Rac1 and Cdc42,230649,5701,1 insect calcium channel blocker,230685,5702,1 insecticidal neurotoxin,230685,5702,1 involved in the pre-mRNA splicing reaction,230702,5703,1 "Antibiotic binding domain of a multidrug resistance transcriptional regulator",230760,5706,1 Biotin carboxyl carrier protein,230869,5711,1 translation initiation factor,230899,5712,1 transfer of a phosphoryl group from ATP to AMP,231045,5720,1 swelling dependent in channel,231378,5736,1 reductase,231466,5740,1 reductase,231489,5741,1 protein required for Cytochrome c oxidase assembly,231512,5742,1 electron transfer protein,231583,5745,1 component of the microsomal fatty acyl desaturase system,231583,5745,1 transfer of a phosphoryl group from ATP to AMP,231610,5746,1 DNA-binding protein,231655,5748,1 antibacterial peptide,231669,5749,1 BAFF-binding domain,231685,5750,1 polypproline binding module,231761,5754,1 Protein tyrosine phosphatse,231778,5755,1 phospho-carrier protein,231835,5757,1 camphor hydroxylase,231877,5759,1 RNA export factor,231974,5764,1 xylan binding,232157,5772,1 dimerization of HIV-1 genome,232180,5773,1 part of Psi encapsidation signal,232180,5773,1 mRNA cleavage and polyadenylation factor,232203,5774,1 RNA recognition,232203,5774,1 binds to phosphatidylinositides,232292,5778,1 regulates membrane-anchoring,232292,5778,1 putative dsDNA mimic,232307,5779,1 antisense,232355,5781,1 "MMP-3 - enzyme involved in wound healing, arthritis and some forms of cancer",232427,5785,1 N-TIMP-1 inhibitor that binds to Matrix Metalloproteinases,232427,5785,1 ribonulease,232468,5787,1 antitumor,232468,5787,1 cytotoxic protein,232468,5787,1 gene regulation,232520,5789,1 antifungal peptide,232663,5795,1 ribosome binding factor,232683,5796,1 hydrolase,232745,5799,1 the reduction of semidehydroascorbate (ascorbate radical),232837,5802,1 Hydrolase(O-Glycosyl),232865,5803,1 Hydrolase(O-Glycosyl),232888,5804,1 antimicrobial,232935,5806,1 regulation of gene transcription,232970,5808,1 "oxygen carrier oxygen transport",232996,5809,1 "cysteine proteinase inhibitor inhibits Staphylococcus aureus staphopain A Staphylococcus epidermidis cysteine protease",233024,5810,1 Regulator of Apoptosis,233103,5814,1 bacteriophage coat protein,233134,5815,1 alkyl hydroperoxyde reductase,233154,5816,1 peroxydase,233154,5816,1 electron transfer protein,233227,5819,1 S-methylation,233259,5820,1 drug metabolism,233259,5820,1 KaiC autophosphorylation enhancer,233327,5824,1 KaiC autophosphorylation enhancer,233353,5825,1 Selectively acting on tetrodotoxin-sensitive voltage-gated sodium channels,233458,5832,1 induces a programmed -1 frameshift during translation of the HIV-1 genes,233488,5834,1 anti-tumor agent,233511,5835,1 cytotoxic protein,233511,5835,1 ribonuclease,233511,5835,1 excessively activates T cells,233523,5836,1 nNOS inhibitor,233611,5840,1 phosphoprotein binding domain of KAPP,233632,5841,1 "MAY BE INVOLVED IN THE FORMATION OR REPAIR OF [FE-S] CLUSTERS PRESENT IN IRON-SULFUR PROTEINS (POTENTIAL).",233662,5842,1 putative GCN5-related N-acetyltransferase,233783,5845,1 histidine kinase inhibitor,233839,5847,1 Ribozyme,233955,5852,1 converts nicotinic acid adenine dinucleotide into NAD+,234015,5854,1 Electron transfer in photosynthesis,234097,5858,1 transcription inhibitor,234158,5859,1 bacteriocin,234193,5860,1 Self-association,234231,5862,1 binding to TNFR1-DD,234231,5862,1 Rip-DD and FADD-DD,234231,5862,1 peptidyl-prolyl cis/trans isomerase(PPIase),234254,5863,1 molecular chaperone,234254,5863,1 "neuromodulatory, neuroprotective",234295,5864,1 allergen,234439,5871,1 repressor of the b-lactamase gene,234471,5873,1 regulatory protein,234471,5873,1 "adaptor protein of the ATPase p97 in the mediation of cellular processes including membrane fusion",234497,5874,1 Immunoglobulin Binding Protein G,234521,5875,1 "adaptor protein of the ATPase p97 in the mediation of cellular processes including membrane fusion",234558,5876,1 Bacterial host adherence factor,234639,5879,1 Pilin,234639,5879,1 Virulence factor,234639,5879,1 trimerization of h-EMILIN-1,234694,5882,1 cell-adhesion promoting function,234694,5882,1 antimicrobial peptide,234719,5883,1 transcription factor,234739,5884,1 PORTION OF A MULTIENZYME COMPLEX FOR BIOSYNTHESIS OF 6-deoxyerythronolide B BY SACCHAROPOLYSPORA ERYTHRAEA,234756,5885,1 antimicrobial peptide,234886,5890,1 DNA-binding,234910,5891,1 Regulation of histone mRNA gene expression,234991,5894,1 translation regulator for histone genes,234991,5894,1 Calcium binding protein,235014,5895,1 Zinc binding protein,235014,5895,1 human bcl-2 homolog involved in apoptosis regulation,235065,5897,1 heparin-binding protein,235170,5902,1 DNA-binding protein,235251,5905,1 chromatin protein,235251,5905,1 function unknown,235251,5905,1 DNA repair,235284,5907,1 DNA-binding protein,235321,5908,1 chromatin protein,235321,5908,1 function unknown,235321,5908,1 DNA-binding chromosomal protein,235347,5909,1 function unknown,235347,5909,1 DNA-binding chromosomal protein,235372,5910,1 function unknown,235372,5910,1 antimicrobial peptide,235496,5916,1 RNA degradation in RNA-DNA hybrids,235537,5918,1 DNA binding domain,235586,5920,1 putative anti-sigma-factor antagonist,235601,5921,1 ion-channel,235617,5922,1 adapter protein,235636,5923,1 chaperonin,235798,5930,1 Catalyzes the cleavage of the RNA portion of a DNA/RNA hybrid,235813,5931,1 Regulatory role and Binding domain to Adaptor Ste50,235874,5933,1 phosphatase,235921,5935,1 chaperonin,235941,5936,1 antimicrobial peptide,235986,5938,1 involved in Raf/Ras pathway,236002,5939,1 binds interleukin-6,236037,5940,1 antimicrobial peptide,236051,5941,1 T cell activation,236104,5944,1 T cell development,236104,5944,1 T cell development,236140,5945,1 Bacterial adhesin,236189,5947,1 putative cell division regulator,236277,5950,1 Actin dynamics,236371,5955,1 Transcription factor,236398,5956,1 phosphoprotein binding domain,236435,5959,1 LRP receptor unit,236485,5961,1 ligand binding repeat,236485,5961,1 minimal binding unit,236485,5961,1 catalytic domain of a self-splicing group II intron ribozyme,236503,5962,1 antibiotics,236628,5969,1 Receptor Binding Domain,236688,5971,1 Putative Osmosensing Coiled-coil,236715,5972,1 guanine nucleotide exchange factor for Rho GTPases,236759,5974,1 human lipoprotein metabolism,236954,5982,1 synthetase,236967,5983,1 TOXIN,237040,5986,1 alpha-neurotoxin,237086,5988,1 cell lysis,237107,5989,1 transcription factor,237138,5991,1 pheromone binding,237246,5995,1 pheromone binding,237293,5996,1 Conserved protein of unknown biological function,237373,5998,1 nucleic acid binding domain,237402,5999,1 protein-protein interactions in complement membrane attack complex,237486,6001,1 "BfpA, the structural subunit of BFP filaments required for localized adherence and autoaggregation of EPEC.",237540,6003,1 "F-actin and G-actin binding. Actin depolymerizing protein which modifies the twist of F-actin when bound.",237565,6004,1 mRNA degradation,237593,6005,1 single-stranded RNA binding,237593,6005,1 cardioactive peptide,237622,6006,1 insect ecdysis regulator,237622,6006,1 Plasminogen kringle 4 binding,237640,6007,1 apolipoprotein(a) kringle 4 type 10 binding,237640,6007,1 hepatocyte growth factor binding,237640,6007,1 tissue-type plasminogen activator binding,237640,6007,1 potential thrombin inhibitor,237670,6009,1 dsrH protein,237692,6010,1 protein-protein recognition,237753,6013,1 muscle assembly and regulation,237796,6015,1 membrane-associated aspartic protease,237823,6016,1 histone-like DNA binding protein,237878,6019,1 antimicrobial peptide,237892,6020,1 Copper Transporter,237928,6022,1 protein phosphatase,237950,6023,1 Hydrolase,237976,6024,1 a chemotactic factor to human neutrophils,237995,6025,1 ribosomal protein S17E,238085,6028,1 nucleotide binding domain,238115,6029,1 nucleotide binding domain,238140,6030,1 actin filament-binding protein,238179,6032,1 electron donor to nitrite reductase,238400,6043,1 ectodomain a viral envelope protein,238451,6046,1 "It cleaves the carbon-mercury bond of alkylmercury and arylmercury compounds in the presence of cysteine or other thiols, releasing mercury as a mercaptide",238464,6047,1 DNA methyltransferase,238598,6053,1 DNA methyltransferase,238619,6054,1 organomercurial lyase,238635,6055,1 signal transduction,238694,6057,1 NADPH oxidase,238694,6057,1 Ras-effektor,238734,6059,1 Membran-binding,238734,6059,1 Apoptosis,238734,6059,1 binding to TolB protein,238792,6061,1 pseudo-5' splice site part of a splicing suppressor of Rous Sarcoma virus,238818,6062,1 antibacterial,238936,6069,1 vasoconstricted peptide,238953,6070,1 metabolism of asymmetric methylarginines,239051,6074,1 protein tyrosine phosphatase,239170,6080,1 muscle contraction,239189,6081,1 calcium binding,239189,6081,1 asynchronous oscillatory contraction of fly wings,239189,6081,1 storage protein,239218,6082,1 antimicrobial,239259,6085,1 involved in iron uptake regulation (by homology),239259,6085,1 viroporin,239304,6087,1 Lipid transfer,239342,6089,1 genome packaging signal,239443,6094,1 formation and maintenance of the myelin sheath,239574,6100,1 inhibitor of cyclin dependent kinases,239810,6112,1 esterolytic antibody,253037,6785,1 X11alpha can form complexes with proteins involved in intracellular trafficking,239824,6113,1 DNA damage signalling,239841,6114,1 activation of transcription,239841,6114,1 cell cycle regulation,239841,6114,1 putative cation transport regulator,239889,6117,1 thiol disulfide oxidoreductase,239904,6118,1 RNA binding protein,239934,6121,1 RNase E plays a crucial role in mRNA degradation in E.coli,239949,6122,1 chitin binding lectin,239968,6123,1 enolase-phosphatase,239987,6125,1 alkyl hydroperoxide reductase,240137,6132,1 Histidine Phosphotransferase,240155,6133,1 Lipid binding,240171,6134,1 Sodium channel inhibitor,240187,6135,1 Sugar transporter,240203,6136,1 seed storage protein,240221,6137,1 bacterial cell wall precursor,240362,6145,1 C4b-binding,240449,6149,1 cell-cell adhesion,240603,6159,1 DNA-binding domain,240633,6161,1 linker histone,240633,6161,1 DNA-binding domain,240649,6162,1 linker histone,240649,6162,1 transcription factor,240664,6163,1 Calcium storage,240716,6167,1 DNA-binding,240716,6167,1 ribosomal tRNA binding protein also invloved in apoptosis,240829,6173,1 chaperone,240901,6176,1 RNA binding protein,240933,6177,1 RNA binding module,240961,6178,1 Kazal-type,240980,6179,1 serine proteinase inhibitor,240980,6179,1 serine proteinase inhibitor,240996,6180,1 Kazal-type,240996,6180,1 protein kinase catalytic domain,241046,6183,1 insect calcium channel blocker,241221,6192,1 insecticidal neurotoxin,241221,6192,1 insect calcium channel blocker,241256,6194,1 insecticidal neurotoxin,241256,6194,1 Dual-specificity tyrosine phosphatase,241273,6195,1 Dual-specificity tyrosine phosphatase,241294,6196,1 signal transduction,241315,6197,1 cytoskeletal organisation,241315,6197,1 binding to specific prolin-rich sequence motifs,241315,6197,1 calcium binding,241395,6201,1 cell adhesion,241395,6201,1 immunity protein,241582,6211,1 scaffold protein,241798,6224,1 domain of a ser/thr kinase,241894,6228,1 regulation of cell growth,241894,6228,1 Protein chaperone,241911,6229,1 ATPase,241911,6229,1 oxygen carrier,241949,6230,1 oxygen transport,241949,6230,1 lectin,241972,6231,1 involved in neurotransmitter release,242043,6235,1 Thrombin inhibitor,242218,6242,1 ubiquitin-protein ligase,242381,6248,1 Periplasmic component of Type III Secretion System of Enteropathogenic E. coli,242460,6252,1 unknown,242567,6256,1 protein-protein interaction,242837,6268,1 regulation of virulence gene expression in Pseudomonas aeruginosa bacteria,242890,6271,1 "DNA sequence present in the VC1620 gene region of the first (of 2) circular chromosome of the pathogenic Vibrio Cholerae. This region contains an authentic point mutation.",242933,6273,1 transcription factor,242971,6275,1 metalloregulatory protein,242971,6275,1 transcription factor,243002,6276,1 metalloregulatory protein,243002,6276,1 ubiquitin conjugating enzyme,243027,6277,1 angiogenesis promoter,243064,6279,1 ribonuclease,243064,6279,1 microbicidal protein,243064,6279,1 involved in neurotransmitter release,243126,6281,1 "The binding of SMRT to the deacetylase domain (HDAC3) promotes modification of chromatin structure. This process is directly related to repression of transcription.",243223,6286,1 "Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to muscular and neuronal (only alpha-7 alpha-8 alpha-9) nicotinic acetylcholine receptors (By similarity).",243266,6288,1 hypothetical membrane protein,243328,6291,1 protease inhibitor,243357,6292,1 oxidoreductase,243420,6295,1 kinase,243476,6297,1 "Sumoylation (covalent isopeptide linkage of Gly97 to the side chain amino group of a lysine in a target protein)",243661,6304,1 "C-domain of Ran GTP-activating protein, site of sumoylation",243680,6305,1 "C-domain of Ran GTP-activating protein, site of sumoylation",243701,6306,1 cell adhesion,243805,6312,1 pheromone transport protein,243826,6313,1 cold shock protein,243844,6314,1 mRNA destabilization factor,243869,6315,1 repression of cytolysin genes,243882,6317,1 transcription factor,243882,6317,1 oxidoreductase,243901,6318,1 Photosensor,243973,6321,1 unknown,244433,6343,1 Rac1/Rnd1 small GTPase binding,244496,6346,1 light-harvesting,244544,6348,1 potassium channel inhibitor,244607,6351,1 Hydrolase,244738,6357,1 antimicrobial peptide,244813,6360,1 DNA binding,244835,6361,1 4-way DNA binding,244835,6361,1 chromatin supercoil inducing,244835,6361,1 protein-protein interaction motif,245114,6374,1 Energy Transducer,245139,6375,1 anti-fungal,245376,6388,1 anti-microbial,245376,6388,1 toxin,245396,6389,1 degrades elastin,245427,6391,1 Bacterial cell division,245504,6395,1 NADPH oxidase,245573,6399,1 calcium dependent membrane binding module,253090,6787,1 inflammation,260481,7222,1 "A T cell receptor Va domain with specificity for the HIV envelope glycoprotein 120-derived peptide P18-I10 bound to the murine MHC class I molecule, H-2Dd.",245729,6406,1 induced the p53 ubiquitination,245767,6407,1 oncoprotein,245767,6407,1 transcription factor,245788,6408,1 metalloregulatory protein,245788,6408,1 transcription factor,245811,6409,1 metalloregulatory protein,245811,6409,1 Hydrolase(O-Glycosyl),245950,6415,1 Periplasmic nickel binding protein,245972,6416,1 antifreeze protein,246198,6427,1 HIV-1 integrase inhibitor,246277,6430,1 "In skeletal muscle the II-III loop forms a physical interaction with the foot region of the ryanodine receptor (RyR) and any structural change in the II-III loop structure is thought to be transmitted to the RyR via this interaction.",246306,6431,1 calcium binding,246356,6433,1 signal transduction,246356,6433,1 involved in tail spike assembly with gpV,246378,6434,1 transcription factor,246613,6445,1 metalloregulatory protein,246613,6445,1 chaperone for the type III secretion of Map,246771,6451,1 chaperone for the type III secretion of Tir,246771,6451,1 biological signalling,246911,6458,1 protein degradation,246911,6458,1 Ubiquitin ligase,246925,6459,1 cell signalling,247064,6466,1 protein degradation,247064,6466,1 protein kinase,247108,6468,1 ATP dependent protein degradation,247151,6470,1 cell signalling,247151,6470,1 pThr/Ser binding domain,247183,6474,1 Protein degradation,247510,6488,1 beta-catenin ubiquitination,247638,6498,1 antibiotic,247662,6499,1 beta-catenin ubiquitination,247694,6500,1 virus genome replication and transcription,247713,6501,1 component of sulfide oxidation system in Allochromatium vinosum,248068,6518,1 putative gamma subunit of dissimilatory sulfite reductase,248068,6518,1 calcium-binding,248082,6519,1 Transcription factor,248111,6521,1 Oligomerization domain,248111,6521,1 Transcription factor,248130,6522,1 antifungal and insecticidal activities,248169,6525,1 "DNA replication, recombination and repair",248350,6535,1 WRN protein plays an important role in preventing premature human aging.,248436,6540,1 "The WRN protein is involved in the DNA replication, repair, recombination and transcription.",248436,6540,1 "The WH subdomain of RQC domain of WRN is involved in the interaction with many proteins and specific structured DNA.",248436,6540,1 Energy buffering,248490,6542,1 Phosphoryl transfer between MgATP and arginine,248490,6542,1 Measles virus polymerase-nucleocapsid interaction,248942,6567,1 Measles virus polymerase-nucleocapsid interaction,248973,6569,1 non-recpetor tyrosin kinase,248989,6570,1 F-actin binding,248989,6570,1 cell adhesion,248989,6570,1 cytokine signalling,249207,6580,1 implicated in caclium release in heart,249282,6583,1 may regulate cytoskeleton,249282,6583,1 ubiquitin-protein ligase,249299,6584,1 co-chaperone,249342,6586,1 Participates in transport of proteins in the chloroplast,249393,6589,1 chitin binding lectin,249436,6591,1 Protein targetting,249474,6593,1 peptidylprolyl isomerase,249647,6601,1 E Coli Methyl Phosphotriester DNA repair protein,249717,6605,1 SYNTHETIC,249771,6608,1 Two-component signal transduction,249832,6611,1 lytic peptide,249903,6616,1 lytic peptide,249937,6618,1 lytic peptide,249955,6619,1 heme binding protein,249987,6620,1 antimicrobial,250125,6627,1 antiviral,250125,6627,1 cytotoxic,250125,6627,1 defence peptide,250125,6627,1 hemolitic,250125,6627,1 insecticidal,250125,6627,1 chitin binding lectin,250292,6637,1 chitin binding lectin,250331,6639,1 catalyzes the reduction of dihyrofolate(DHFR) to tetrahydrofolate (THF),250438,6645,1 chitin binding lectin,250471,6647,1 metalloregulatory protein,250496,6648,1 Transcription factor,250496,6648,1 hemolytic,250562,6650,1 hemolytic,250586,6651,1 Transcription factor,250631,6653,1 metalloregulatory protein,250631,6653,1 dsRNA binding,250666,6655,1 chitin binding lectin,250709,6656,1 chitin binding lectin,250735,6657,1 plays a role in the centriole duplication,251281,6687,1 Possible Secreted Virulence Factor,251308,6688,1 Unknown,251308,6688,1 Photoreceptor,251416,6692,1 Activation NADPH oxidase,251663,6710,1 Signal transduction,251663,6710,1 ubiquitin conjugating enzyme,251680,6711,1 Activation NADPH oxidase,251710,6713,1 Signal transduction,251710,6713,1 heme chaperone,251941,6723,1 potassium channel,252036,6728,1 de-ubiquitinase,252294,6742,1 Alternative splicing regulation,252337,6745,1 phnA-like protein,252351,6746,1 50S ribosomal protein L40e,252377,6747,1 lipid binding,252464,6752,1 group II intron branch point domain,252518,6756,1 membrane anchor domain,252537,6757,1 Catalytic subunit of EcCDT-II,252568,6758,1 prophage excisionase,252660,6762,1 inhibitor of the Tor sytem,252660,6762,1 kinase inducible transactivation domain,253010,6784,1 kinase inducible transactivation domain,253106,6788,1 Inhibitor of Juvenile Hormone production in Corpora Allata of cockroach Diploptera Punctata,253189,6791,1 Inhibitor of gut muscle contraction in Diploptera Puncata,253189,6791,1 Inhibitor of Juvenile Hormone production in Corpora Allata of cockroach Diploptera Punctata,253206,6792,1 Inhibitor of gut muscle contraction in Diploptera Puncata,253206,6792,1 cysteine peptidase inhibitor,253236,6794,1 Receptor Binding Domain,253337,6800,1 Iron(III) Dicitrate Transport Protein FecA,253392,6803,1 aspartate phosphotransferase activity,253501,6810,1 protease,253777,6823,1 DNA binding,253851,6826,1 chitin binding,253903,6829,1 hydrolyze a range of complex ester-linked triglycerides,253965,6832,1 assembly of synaptic signaling complexes,254081,6837,1 Hydrolyzes beta-lactams,254111,6838,1 palmitoyl group recognition,254176,6840,1 DNA repair,254361,6851,1 structural,254431,6856,1 imunodominant epitope of mylin basic protein,254449,6857,1 structural,254474,6858,1 lytic peptide,254493,6859,1 lipid headgroup binding (pip's),254764,6873,1 exhibits angiogenic and a variety of growth an differentiation activities,254806,6875,1 transcription factor,254853,6877,1 Potassium channel,254883,6879,1 protease inhibitor,254904,6880,1 protease,254921,6881,1 protease inhibitor,254921,6881,1 Protein component of the antitumour antibiotic Neocarzinostatin,255033,6888,1 Transcription factor,255366,6905,1 Inhibits survival and neurite formation of cortical neurons in vitro; Binds zinc and copper(I)in brain; Metal storage protein,255425,6909,1 protein-protein interaction domain,255455,6911,1 ATP-dependent copper transport,255500,6914,1 binding alpha-4,255597,6920,1 ubiqutin E3 ligase,255597,6920,1 electron carrier protein,255611,6921,1 RNA splicing factor,255749,6930,1 snRNP protein,255749,6930,1 hydrolyze a range of complex ester-linked triglycerides,255808,6935,1 deubiquitylation,255858,6939,1 protein-protein interaction,255858,6939,1 transcriptional regulator,255979,6947,1 "the dimeric protein is a transcriptional regulator, activity of monomeric form not yet defined",255999,6948,1 trypsin inhibitor,256213,6963,1 electron transfer protein,256243,6965,1 electron-transfer mediator in bacterial respiratory chain,256263,6966,1 electron-transfer mediator in bacterial respiratory chain,256280,6967,1 co-chaperone,256372,6973,1 co-chaperone,256386,6974,1 Heme metabolism in P. aeruginosa,256498,6983,1 cAMP Binding,256515,6984,1 PKA Regulation,256515,6984,1 transcritpional regulation,256531,6985,1 Phosphotyrosine binding,256551,6986,1 Heme metabolism in P. aeruginosa,256567,6987,1 Cell signaling,256645,6991,1 Cell signaling,256682,6993,1 Cell signaling,256718,6996,1 Cell signaling,256753,6998,1 unknown,256810,7000,1 mRNA nuclear export factor,257236,7023,1 peptidyl-tRNA hydrolase,257575,7055,1 RNA-polymerase,257599,7056,1 splicing protein,257923,7070,1 U6 RNP,257923,7070,1 conserved hypothetical protein,258029,7075,1 polymerization domain of tropomyosin,258092,7080,1 troponin binding site,258092,7080,1 dimerization,258152,7082,1 DNA binding,258152,7082,1 carbohydrate-binding,258177,7083,1 hypothetical protein,258207,7085,1 hypothetical protein,258235,7086,1 degrades elastin and alpha1-antitrypsin,258301,7089,1 antisens target,258322,7090,1 coding for P-gp,258322,7090,1 Antimicrobial,258346,7092,1 plant defensin,258346,7092,1 translation initiation factor,258717,7115,1 Insect toxin,258751,7117,1 E3 ligase,258874,7124,1 Oxygen transportation,258890,7125,1 ribonuclease-inhibitor complex,258910,7126,1 Structural protein,258959,7128,1 domain of multi-domain mannose-6-phosphate receptor,259007,7131,1 ribonuclease-inhibitor complex,259115,7139,1 cell comunication,259144,7140,1 signal transduction,259144,7140,1 carrier of retinol,259208,7149,1 membrane-binding,259243,7151,1 Nuclear pore protein,259346,7158,1 Cytoskeletal membrane crosslinker,259394,7161,1 protein modifier,259424,7165,1 Sodium channel blocker,259438,7166,1 Actin binding protein,259534,7172,1 Immunity protein to Colicin E7,259791,7188,1 calcium- binding,259822,7190,1 storage particle,259888,7194,1 transcription factor,259888,7194,1 Transcriptional repressor,259999,7203,1 not available,260133,7208,1 Pilot protein required for pilus assembly in bacteria,260159,7209,1 histone binding,260183,7210,1 tumour suppressor,260183,7210,1 inhibit nAChR function and block neurotransmission,260216,7211,1 antigen mimic,260238,7212,1 antigen mimic,260260,7213,1 antigen mimic,260282,7214,1 antigen mimic,260304,7215,1 arthritis,260432,7221,1 inflammation,260432,7221,1 arthritis,260481,7222,1 mutase,260800,7234,1 mutase,260829,7235,1 Cyclic amide hydrolase (beta-lactamase) (E.C. 3.5.2.6),260853,7236,1 Cyclic amide hydrolase (beta-lactamase) (E.C. 3.5.2.6),260873,7237,1 Cyclic amide hydrolase (beta-lactamase) (E.C. 3.5.2.6),260893,7238,1 Cyclic amide hydrolase (beta-lactamase) (E.C. 3.5.2.6),260913,7239,1 chaperon,261112,7248,1 component of U4 snRNP,261130,7249,1 Insulin like growth factor regulation,261420,7262,1 Cellulase,261460,7264,1 Xylanase,261460,7264,1 unknown,261482,7266,1 Allergen,261657,7276,1 Unknown in mites,261657,7276,1 chromatin associated,261732,7279,1 DNA-binding,261732,7279,1 immunoglobulin binding,261748,7280,1 cellulosome assembly,261828,7285,1 phosphatidylethanolamine binding protein,261854,7286,1 antibiotic,262035,7294,1 antifungal,262035,7294,1 bacterial respiration,262085,7296,1 electron transport chain,262085,7296,1 conserved hypotetical Zn-binding protein,262106,7297,1 ubiquitin binding domain,262132,7298,1 signalling protein,262264,7305,1 signalling protein,262278,7306,1 apoptasis marker for neutrophils,262416,7313,1 Inhibitor protein of the endonuclease Colicin E7.,262487,7316,1 Inhibitor protein of the endonuclease Colicin E7.,262505,7317,1 Inhibitor protein of the endonuclease Colicin E7.,262523,7318,1 LH1+RC dimerisation,262561,7320,1 receptor activation,262576,7321,1 May be involved in a redox-related process,262621,7324,1 protein disulfide isomerase,262911,7359,1 protein disulfide isomerase,262951,7360,1 Trypsin inhibitor,262978,7361,1 DNA binding,263143,7376,1 transcriptional repressor,263143,7376,1 zinc homeostasis,263143,7376,1 DNA binding,263164,7377,1 transcriptional repressor,263164,7377,1 zinc homeostasis,263164,7377,1 iron-sulfur cluster assembly and transfer,263920,7432,1